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Breast cancer in blacks – 5X increased risk of triple negative if low vitamin D – Oct 2017

Association of Vitamin D3 Level with Breast Cancer Risk and Prognosis in African-American and Hispanic Women

Cancers 2017, 9(10), 144; doi:10.3390/cancers9100144
Yanyuan Wu 1,2, Marianna Sarkissyan 1, Sheilah Clayton 1, Rowan Chlebowski 2,3 and Jaydutt V. Vadgama 1,2,*


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Background: This study investigated the association of vitamin D3 levels with breast cancer risk and progression in African-Americans and Hispanics. Methods: A total of 237 African-American (Cases = 119, Control = 118) and 423 Hispanic women (Cases = 124, Control = 299) were recruited in the study. Blood samples were collected at the time of breast cancer screening and prior to cancer treatment for 4 weeks on average for the cases. The serum 25-hydroxyvitamin D (25(OH)D3) was measured at a Quest-Diagnostics facility.

Results: The results showed that 69.2% of African-Americans and 37.8% of Hispanics had 25(OH)D3 levels below 20 ng/mL. The 25(OH)D3 level below 20 ng/mL was significantly associated with breast cancer in both African-Americans (OR = 2.5, 95% CI = 1.3–4.8) and Hispanics (OR = 1.9, 95% CI = 1.1–3.0). However, the predicted probabilities of breast cancer in African-Americans were significantly higher than in Hispanics (p < 0.001).

The 25(OH)D3 below 20 ng/mL was significantly associated with triple negative breast cancer (TNBC) in African-Americans (OR = 5.4, p = 0.02, 95% CI = 1.4–15), but not in Hispanics in our cohort of participants. Levels of 25(OH)D3 below 26 ng/mL predicts a decrease in disease-free survival, but it was not an independent predictor.

Conclusions: Our data shows an association between 25(OH)D3 levels and the risk of breast cancer. Further studies on the relationship between 25(OH)D3 level and breast cancer risk are warranted.

Created by admin. Last Modification: Wednesday November 1, 2017 18:13:57 UTC by admin. (Version 5)

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8623 5X 3 negative black breast cancer.pdf PDF 2017 admin 01 Nov, 2017 17:45 824.45 Kb 5
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