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Breast Cancer was 4.6 times more likely if have a poor Vitamin D Receptor – Dec 2016

Vitamin D status, receptor gene BsmI (A/G) polymorphism and breast cancer in a group of Egyptian females

Egyptian Journal of Medical Human Genetics, http://dx.doi.org/10.1016/j.ejmhg.2016.11.003
Rasha Rizk Elzeherya, , , Azza A. Baiomya, , Mohamed AbdEl-Fattah Hegazyb, , Rami Faresb, , Abdel-Hady El-Gilanyc, , Refaat Hegazid,

VitaminDWiki

Vitamin D Receptor category has the following

190 items in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

A poor VDR increases the risk of 37 health problems  click here for details

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
You can compensate for poor VDR by increasing one or more of the following:

IncreasingIncreases
1) Vitamin D supplement
  Sun, Ultraviolet -B
Vitamin D in the blood
and thus to the cells
2) MagnesiumVitamin D in the blood
 AND to the cells
3) Omega-3 Vitamin D to the cells
4) Resveratrol Vitamin D to the cells
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor


Items in both VitaminDWiki categories Breast Cancer and Vitamin D Receptor are listed here:


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Background
Vitamin D is involved in a wide variety of biological processes including bone metabolism, modulation of the immune response, and regulation of cell proliferation and differentiation. The present study aimed to investigate vitamin D status and the genetic polymorphism BsmI (A/G) of vitamin D receptor (VDR) among a group of Egyptian female patients with breast cancer.

Methods
The current study included 60 female patients diagnosed as breast cancer (BC) attending Mansoura Oncology Center, Mansoura University, and 60 age-matched healthy control females. Serum 25(OH) vitamin D level was measured using Enzyme-linked immunosorbent assay (ELISA) kit. A polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) method and fragment analysis were performed to determine the VDR BsmI (A/G) polymorphism.

Results
25(OH) vitamin D levels were significantly lower in the patients with BC (22.1 ± 10.9 ng/ml) compared to controls (41.2 ± 11.22 ng/ml) (p 0.001). Vitamin D deficiency- insufficiency was reported in 76.7% of BC patients and 20% of the controls (P 0.001, OR = 13.1, 95%CI = 5.5 - 31.4).
Bb genotype was statistically higher in the BC patients than in the healthy controls (P 0.001).

  • 81.2% of BC patients were of Bb genotype,
  • 10.9% of BB genotype and
  • 4.3% of bb genotype,

while in controls, 33.3% for each genotype.
No statistically significant difference in allele frequency was observed between the two studied groups.
Carriers of Bb genotype had 4.6 times increased risk of developing breast cancer (95% confidence interval of 2.0–10.3) when compared to other genotypes.

Conclusion
A significant association exists between vitamin D deficiency and the risk of breast cancer. B allele or Bb genotype of VDR may be a susceptibility risk factor for BC development.

Attached files

ID Name Comment Uploaded Size Downloads
7457 BC VDR.pdf PDF 2016 admin 05 Dec, 2016 23:58 361.87 Kb 110
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