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Birth asphyxia 2.4 times more likely if mother was vitamin D deficient – 2016

Maternal vitamin D deficiency and fetal distress/birth asphyxia: a population-based nested case–control study

Obstetrics and gynaecology, http://dx.doi.org/10.1136/bmjopen-2015-009733
Pelle G Lindqvist1,2, Aldo T Silva1, Sven A Gustafsson3, Sebastian Gidlöf1,2,4

See also VitaminDWiki

Healthy pregnancies need lots of vitamin D

has the following summary

1. Miscarriage 2.5 times Observe
2. Pre-eclampsia 3.6 timesRCT*
3. Gestational Diabetes 3 times RCT*
4. Good 2nd trimester sleep quality 3.5 times Observe
5. Vaginosis 10 times RCT*
6. Premature birth 2 times RCT*
7. C-section - unplanned 1.6 timesObserve
8. Depression AFTER pregnancy 1.4 times RCT*
9. Small for Gestational Age 3 times Observe
10. Infant height, weight, head size
     within normal limits
11. Childhood Wheezing 1.3 times RCT*
12. Additional child is Autistic 4 times Intervention
13.Young adult Multiple Sclerosis 1.9 timesObserve
14. Preeclampsia in young adult 3.5 timesRCT*
15. Good motor skills @ age 31.4 times Observe
16. Childhood Mite allergy 5 times RCT*
17. Childhood Respiratory Tract visits 2.5 times RCT*

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Objective Vitamin D deficiency causes not only skeletal problems but also muscle weakness, including heart muscle. If the fetal heart is also affected, it might be more susceptible to fetal distress and birth asphyxia. In this pilot study, we hypothesised that low maternal vitamin D levels are over-represented in pregnancies with fetal distress/birth asphyxia.

Design and setting A population-based nested case–control study.

Patients Banked sera of 2496 women from the 12th week of pregnancy.

Outcome measures Vitamin D levels were analysed using a direct competitive chemiluminescence immunoassay. Vitamin D levels in early gestation in women delivered by emergency caesarean section due to suspected fetal distress were compared to those in controls. Birth asphyxia was defined as Apgar <7 at 5 min and/or umbilical cord pH≤7.15.

Results Vitamin D levels were significantly lower in mothers delivered by emergency caesarean section due to suspected fetal distress (n=53, 43.6±18 nmol/L) compared to controls (n=120, 48.6±19 nmol/L, p=0.04). Birth asphyxia was more common in women with vitamin D deficiency (n=95) in early pregnancy (OR 2.4, 95% CI 1.1 to 5.7).

Conclusions Low vitamin D levels in early pregnancy may be associated with emergency caesarean section due to suspected fetal distress and birth asphyxia. If our findings are supported by further studies, preferably on severe birth asphyxia, vitamin D supplementation/sun exposure in pregnancy may lower the risk of subsequent birth asphyxia.

Attached files

ID Name Comment Uploaded Size Downloads
7865 fetal distress- birth asphyxia.pdf PDF 2016 admin 20 Mar, 2017 17:01 617.50 Kb 26
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