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Autism in children reduced by Vitamin D (used 300 IU per kg per day) – RCT Oct 2016

Randomized controlled trial of vitamin D supplementation in children with autism spectrum disorder

Journal of Child Psychology and Psychiatry, First published: Oct 2016 DOI: 10.1111/jcpp.12652
Khaled Saad, Ahmed A. Abdel-Rahman, Yasser M. Elserogy, Abdulrahman A. Al-Atram,
Amira A. El-Houfey, Hisham A. K. Othman, Geir Bjørklund, Feiyong Jia, Mauricio A. Urbina,
Mohamed Gamil M. Abo-Elela, Faisal-Alkhateeb Ahmad, Khaled A. Abd El-Baseer,
Ahmed E. Ahmed, Ahmad M. Abdel-Salam

VitaminDWiki Summary
At start4 months later
CARS
Autism Rating Scale
3730
Irritability2210
Social Responsiveness
   lower is better
7571
Hyperactivity2616
Lethargy1811
Inappropriate Speech74
Vitamin D
all had > 20 ng at start
26 ng46 ng

VitaminDWiki speculates even more improvements if

  • Only considered those children gettting > 40 ng of Vitamin D
  • Had started with a loading dose (4 months is a fairly short time)
  • Give more Vitamin D to children for poor Vitamin D Receptor - which increases the risk of Autism by 2X
    Note: Vitamin D Receptor test costs $23.
    Wild guess: 50% more vitamin D would be needed for those with poor VDR
  • Had added some cofactors - Magnesium and Omega-3
    Both are often mentioned with Autism and both deal with poor Vitamin D Receptors

See also VitaminDWiki
Files in both categories of Intervention AND Autism

 

1000 IU per 25 lbs.jpg
   This study used a dose which was 3X larger: 300 IU/kg == 3,000 IU/25 lbs
Autism treated by Vitamin D: Dr. Cannell - video June 2013
includes many reasons why he believes Autism is related to Vitamin D

  1. Both have strong inheritance features – Vitamin D about 60%
  2. Both have gotten substantially worse in last 30 years
  3. Vitamin D is known to be involved in brain development
  4. All autistic children are VitD deficient, but not all children who are deficient are autistic: genes are involved
  5. When giving vitamin D to cure children of rickets “mental dullness” decreases as well
  6. Children with genes which give them too much (Williams Syndrome) have to reverse of autism – too sociable
  7. Mothers having lots of fish (and thus more vitamin D) give birth to kids with less autistic symptoms
  8. Both associated with weak bones
  9. Both worse around the age of weaning
  10. Autism is more common in rich families – more likely to apply sun screen and stay indoors
  11. Autism increases with drugs which lower levels of vitamin D
  12. Seizures are common with Autism - Vitamin D has been shown to reduce seizures
  13. Fewer autistic symptoms (such as sleep problems) during summer: when child gets more vitamin D from the sun
  14. Both worse with latitude
  15. Both vary with Ultraviolet light
  16. Both vary with time of year (more birth of autistics in March in Northern hemisphere)
  17. 2X more urban autism – less UVB in urban environments
  18. Both worse with pollution
  19. Both worse with increased clouds and rain
  20. Both worse with closely spaced pregnancies
  21. Autistics have abnormal immune response – similar to that of vitamin D deficiency
  22. Low levels of vitamin D in mother animals reduces brain function in offspring
  23. Vitamin deficient rat pups have similar brain abnormalities to that of human autistic children
  24. Autistic children get less vitamin D in their blood for the same amount of sun exposure
  25. The 4 males/1 female ratio - Note estrogen increases vitamin D in the brain (testosterone does not)
  26. Both worse in African Americans (A-A 2-3 increased autism rate)
  27. Both worse in Dark-skinned immigrants in Europe


Background:
Autism spectrum disorder (ASD) is a frequent developmental disorder characterized by pervasive deficits in social interaction, impairment in verbal and nonverbal communication, and stereotyped patterns of interests and activities. It has been previously reported that there is vitamin D deficiency in autistic children; however, there is a lack of randomized controlled trials of vitamin D supplementation in ASD children.

Methods
This study is a double-blinded, randomized clinical trial (RCT) that was conducted on 109 children with ASD (85 boys and 24 girls; aged 3–10 years). The aim of this study was to assess the effects of vitamin D supplementation on the core symptoms of autism in children. ASD patients were randomized to receive vitamin D3 or placebo for 4 months. The serum levels of 25-hydroxycholecalciferol (25 (OH)D) were measured at the beginning and at the end of the study. The autism severity and social maturity of the children were assessed by the Childhood Autism Rating Scale (CARS), Aberrant Behavior Checklist (ABC), Social Responsiveness Scale (SRS), and the Autism Treatment Evaluation Checklist (ATEC). Trial registration number: UMIN-CTR Study Design: trial number: UMIN000020281.

Results
Supplementation of vitamin D was well tolerated by the ASD children. The daily doses used in the therapy group was 300 IU vitamin D3/kg/day, not to exceed 5,000 IU/day. The autism symptoms of the children improved significantly, following 4-month vitamin D3 supplementation, but not in the placebo group. This study demonstrates the efficacy and tolerability of high doses of vitamin D3 in children with ASD.

Conclusions
This study is the first double-blinded RCT proving the efficacy of vitamin D3 in ASD patients. Depending on the parameters measured in the study, oral vitamin D supplementation may safely improve signs and symptoms of ASD and could be recommended for children with ASD. At this stage, this study is a single RCT with a small number of patients, and a great deal of additional wide-scale studies are needed to critically validate the efficacy of vitamin D in ASD.

Publisher rents PDF for $6


Social Responsiveness (SRS) of 22,000 Japanese school children - lower score is better
Image

Attached files

ID Name Comment Uploaded Size Downloads
7403 SRS.jpg admin 27 Nov, 2016 02:23 24.84 Kb 612
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