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Alzheimers-Cognition - Overview

Summary of Alzheimers and Vitamin D

Table of contents

Alzheimer's in VitaminDWiki

The items in both Cognition and Meta-analysis categories:

Cognition and Dementia in VitaminDWiki

Items in BOTH Cognition and Intervention categories

   give Vitamin D and look for improved cognition

200 patients nicely treated for all 3 types of Alzheimer's by adjusting several of 34 variables - Sept 2017

  • Variables include diet, exercise and supplements (no drugs, did not notice Vitamin D)
  • I would not normally have believed this claim except that it was described by Dr. Doidge, whom I trust after reading his book Missing Microbes
  • includes link to scienfic publication and new book

Alzheimer’s can also result from gene problems NOT detected by Vitamin D blood tests

Items in both Cognition and Vitamin D Receptor categories

Note above: Alzheimer’s 3 times more likely if poor VDR

Vitamin D Receptor category has the following

190 items in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

A poor VDR increases the risk of 37 health problems  click here for details

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
You can compensate for poor VDR by increasing one or more of the following:

IncreasingIncreases
1) Vitamin D supplement
  Sun, Ultraviolet -B
Vitamin D in the blood
and thus to the cells
2) MagnesiumVitamin D in the blood
 AND to the cells
3) Omega-3 Vitamin D to the cells
4) Resveratrol Vitamin D to the cells
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor

Alzheimer’s disease – vitamin D looks promising – Annweiler Jan 2014 has a VDR chart

On the WEB

  • Alzheimer's summary at Vitamin D Council updated Dec 2015
  • 37 minute podcast Vitamin D and the brain Vitamin D Council Sept 2014
    discussion by Dr. Cannell and Dr. David Llewellyn
  • Cognitive Imparement Vitamin D Council update Sept 2017
  • Is Alzheimer’s Type 3 Diabetes? New York Times Sept 2012]
    Idea has been around since 2005. Brain cells become insulin resistant - first noticed by Dr. Alzheimer
    people with diabetes are at least twice as likely to get Alzheimer’s
  • PubMed Alzheimer's AND Insulin in title 264 items as of Oct 2016
  • Vitamin D and neurology WikiPedia
    has sections on Dementia: Alzheimer's disease, Parkinson's disease, Multiple sclerosis, Epilepsy and seizures, Schizophrenia
  • Alzheimer's nutrient status - July 2014 includiing vitamin D - attached at the bottom of this page
  • Vitamin D Deficiency and Alzheimer Disease: Common Links July 2015, Publisher wants $40 for the PDF
    "Based on this accumulation of studies, we propose that VitD screening should be performed at least in those individuals at risk for VitD deficiency and AD"
  • Is It Alzheimer’s, or A.D.H.D.? New York Times Sept 2015
    3 % of Dutch over 60 have A.D.H. D. It overlaps with age-related cognitive decline
  • Probiotics improve cognition in Alzheimer's patients RCT Nov 2016
    Nothing about Vitamin D. 12 weeks of probiotics for Alzheimer's patients increased mental test score from 8.7 to 10.6 (max score = 30)
  • Should I Take The Gene Test For Alzheimer's? GreenMed Info. April 2017
    Yes:should have a gene test, especially if Alz runs in the family
    If you have two copies of APOE4 gene you cam be at 12X risk of getting Alzheimer's
    Personal note: I (Henry Lahore) have just one copu of the gene, so I have a 3X risk - the only gene risk from my 23andMe report
        Supplementing vitamin D, etc virtually eliminates my increased risk*6X increase in Age-Adjusted Death from Dementia (Finland) in 30 years
  • Age-adjusted = increase is NOT due to having a larger elderly population

_Dementia death rate - age standardized @is.gd/increasedisease

  • 6X increase in Age-Adjusted Death from Dementia (Finland) in 30 years
    Age-adjusted = increase is NOT due to having a larger elderly population

Dementia death rate - age standardized @is.gd/increasedisease

  • From Fight Aging On Increasing Your Chances of Avoiding Alzheimer's July 2011
    In many ways, Alzheimer's Disease looks a lot like type 2 diabetes - it can be argued that there are some biochemical similarities in the underlying mechanisms, Alzheimer's appears to be a lifestyle disease to some degree, and the two conditions have many of the same risk factors, such as obesity and being sedentary. So: "Over half of all Alzheimer's disease cases could potentially be prevented through lifestyle changes and treatment or prevention of chronic medical conditions. ...
    Analyzing data from studies around the world involving hundreds of thousands of participants, [researchers] concluded that worldwide, the biggest modifiable risk factors for Alzheimer's disease are, in descending order of magnitude, low education, smoking, physical inactivity, depression, mid-life hypertension, diabetes and mid-life obesity. ...

In the United States, [researchers] found that the biggest modifiable risk factors are

  • physical inactivity,
  • depression,
  • smoking,
  • mid-life hypertension,
  • mid-life obesity,
  • low education and
  • diabetes. ...

Note: EVERY SINGLE ONE of the above associations with Alzheimer's Disease is also associated with low vitamin D:

  • physical inactivity - not get out in the sun
  • depression category - a common result of low vitamin D:
  • Smoking - well known to consume vitamin D
  • mid-life hypertension a result of low vitamin D:
  • mid-life obesity - which results from low vitamin D, and Obesity makes vitamin D levels even lower
  • Low education - take far fewer nutritional supplements - due to cost, knowledge, belief
    • Note: low education is also associated with dark skinned people, who get less vitamin D from the sun
  • diabetes - a result of low vitamin D:

Clinical Trials underway for Cognition and Vitamin D INTERVENTION


Vitamin D, Cognition and Alzheimer's Disease: The Therapeutic Benefit is in the D-Tails - May 2016

J Alzheimers Dis. 2016 May 11;53(2):419-44. doi: 10.3233/JAD-150943.
Landel V1, Annweiler C2,3, Millet P1,4, Morello M1,5,6, Féron F1.
Image
Fig. 2. Proposed mechanisms of vitamin D-mediated multitargeted effects in AD. Vitamin D imbalance is proposed to alter mechanisms implicated in aging and AD pathogenesis. Suggested protective effects of vitamin D supplementation concern regulation of vascular processes and oxidative stress, calcium homeostasis, neurotransmission, modulation of immune and inflammatory processes, and direct impact on amyloidogenesis, ultimately improving cognitive functions.

 Download the PDF from VitaminDWiki


Age-adjusted Death rates: Alzheimer's has been increasing the fastest

Image

Big increase if both parents had Alzheimer's

Image

54% of ALL people, of all ages, are now "touched" by Alzheimer's

Image

Alzheimers Association facts and figures 2016 - nothing about vitamin D

 Download the PDF from VitaminDWiki
Has A LOT of information, including the following

  • "Compared with no TBI, moderate TBI is associated with twice the risk of developing Alzheimer’s and other dementias, and severe TBI with 4.5 times the risk"
  • "1 in 9 people over age 65 has Alzheimer's Disease"
  • "Among people aged 70, 61% of those with Alzheimer's Disease are expected to die before age 80 vs 30% of those without Alzheimers' "
  • "15 million Americans provide unpaid care for people with Alzheimer’s disease and other dementias."
  • "Total payments for Heatlh Care, Long term care, and Hospice are estimated to be $236 billion in 2016 for people with Alzheimer’s disease and other dementias."
    This $236 Billion does NOT include the costs due tor care-giving by family, lost time from work, etc.

Percentage Changes in Selected Causes of Death (All Ages) Between 2000 and 2013

Image

Alzheimer's in more than half of hospital patients over age 65

Image

Half of care-giving for 6+ years is due to Alzheimer's or other dementia

Image

Work changes due to Alzheimer's or Dimentia care-giving

Image


What if we could delay onset of Alzheimer's by 5 years - Alzheimer's Association - 2015

 Download the PDF from VitaminDWiki
Image
Looks like about half of the people would not have Alzheimer's costs (die sooner?)


Cognition other than Vitamin D monotherapy

Magnesium and Mental Health  see  is.gd/VDMag

Items in BOTH Cognition and Omega-3 categories


APOE4 gene greatly increases risk of AD, but had been a benefit during childhood

The APOe4 gene protected our ancestors and helped them get through the child bearing years by attacking parasites and micro-organisms with oxidative stress. It is only in modern times that people live long enough for the same oxidative stress to work against us in old age.
A book, Survival of the Sickest,(2008) points out roughly the same concept in a number of other diseases which long ago helped our ancestors get through plagues, ice ages, parasites, famine, etc. It's a fascinating concept and it makes sense. By Rich H, Jan 2017
 Download the PDF of the book from VitaminDWiki


Small amount of Lithium slowed dementia in Alzheimer's

Rate of a rare form of early-onset Alzheimer's associated with Aluminium - 2017


Bill Gates put $50 million into Alzheimer's Research - Fall 2017 (no mention about Vitamin D)

  • Why I’m Digging Deep Into Alzheimer’s Bill Gates Blog
    "A person with Alzheimer’s or another form of dementia spends five times more every year out-of-pocket on healthcare than a senior without a neurodegenerative condition"
    For example, we don’t fully understand why you are more likely to get Alzheimer’s if you’re African American or Latino than if you’re white"
    VitaminDWiki suspects that the increased risk is due to lower levels of vitamin D in those with dark skins
  • Bill Gates' newest mission: Curing Alzheimer's CNN
    "Since 2002, there have been more than 400 Alzheimer drug trials run and yet no treatments"

Risk of Dementia reduced 50% by just using Brain Plasticity Software for just 13 hours - Nov 2017

Posit Science - 10 year experiment, full free text online
Speed of processing training results in lower risk of dementia

short url = http://is.gd/dcognition

Alzheimers-Cognition - Overview        

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Attached files

ID Name Comment Uploaded Size Downloads
7796 ALZ Fig 2.jpg admin 05 Mar, 2017 22:00 21.45 Kb 2520
7795 Therapeutic Benefit is in the D-Tails.pdf PDF 2016 admin 05 Mar, 2017 21:59 523.25 Kb 254
7627 Survival Of The Sickest - 2008 book.pdf PDF admin 06 Jan, 2017 22:52 947.50 Kb 962
7553 Lithium to the Rescue.pdf PDF 2016 admin 23 Dec, 2016 12:18 670.40 Kb 522
7407 Lithium as Nutrient - 2015.pdf PDF 2015 admin 29 Nov, 2016 11:40 128.16 Kb 431
7406 Lithium and Alz LEF Dec 2016.pdf PDF 2016 admin 28 Nov, 2016 23:56 3.40 Mb 491
7256 If delay onset by 5 years.jpg admin 29 Oct, 2016 14:54 15.97 Kb 2300
7255 Delay Alz by 5 years - 2015.pdf PDF 2015 admin 29 Oct, 2016 14:50 1,015.63 Kb 635
7254 Work changes due to Alz or Dimentia care-giving.jpg admin 29 Oct, 2016 14:12 19.54 Kb 2446
7253 Half of care giving for 6+ years is due to Alzheimer's or other dementia.jpg admin 29 Oct, 2016 14:06 38.45 Kb 2332
7252 Percentage Changes in Selected Causes of Death (All Ages) Between 2000 and 2013.jpg admin 29 Oct, 2016 00:04 21.84 Kb 2450
7251 Alz in more than half of hospital patients over age 65.jpg admin 28 Oct, 2016 23:46 37.59 Kb 2536
7250 Alzheimers Association facts and figures 2016.pdf PDF 2016 admin 28 Oct, 2016 23:45 2.07 Mb 578
7249 Alzheimer's dark skin.jpg admin 28 Oct, 2016 21:22 23.01 Kb 1964
7248 54% touched by Alzheimer's.jpg admin 28 Oct, 2016 21:21 23.94 Kb 2428
7247 Alzheimer's both parents.jpg admin 28 Oct, 2016 21:21 31.71 Kb 2561
4867 Dementia incidence.jpg admin 12 Jan, 2015 02:24 61.75 Kb 7426
4095 Alz nutrient status.pdf PDF 2014 admin 29 Jun, 2014 10:54 1.57 Mb 1355
3475 Death rates alzheimers.gif admin 02 Jan, 2014 17:37 38.58 Kb 13366
3469 Alzheimers percentage.png admin 29 Dec, 2013 11:57 49.40 Kb 24531
1131 Alzheimer\'s 2011.pdf PDF admin 04 Mar, 2012 15:28 1.09 Mb 1812
1130 Alz in hospital - 2011.jpg Go to hospital with Alz admin 04 Mar, 2012 15:24 34.72 Kb 9189
1129 Alz how long - 2011.jpg how long care needed admin 04 Mar, 2012 15:23 28.67 Kb 8827
1128 Alz F5 - 2011.jpg increases admin 04 Mar, 2012 15:23 20.73 Kb 9038
1120 Potential targets for Alz.jpg targets from D-Mentia admin 26 Feb, 2012 21:01 21.24 Kb 11272
1119 Vitamin D-mentia.pdf admin 26 Feb, 2012 21:00 292.71 Kb 2134
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