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Alzheimers-Cognition - Overview

Summary


Alzheimer's in VitaminDWiki

The items in both Cognition and Meta-analysis categories:

Cognition and Dementia in VitaminDWiki

Items in BOTH Cognition and Intervention categories

   give Vitamin D and look for improved cognition

Alzheimer’s can also result from gene problems NOT detected by Vitamin D blood tests

Items in both Cognition and Vitamin D Receptor categories

Note above: Alzheimer’s 3 times more likely if poor VDR

Vitamin D Receptor category has the following

144 items in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
A poor VDR increases the risk of 29+ health problems  click here for details

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
You can compensate for poor VDR by increasing one or more of the following:

IncreasingIncreases
1) Vitamin D supplement
  Sun, Ultraviolet -B
Vitamin D in the blood
and thus to the cells
2) MagnesiumVitamin D in the blood
 AND to the cells
3) Omega-3 Vitamin D to the cells
4) Resveratrol Vitamin D to the cells
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor

Alzheimer’s disease – vitamin D looks promising – Annweiler Jan 2014 has a VDR chart

- - - - - - - On the WEB - - - - - - - - - - - - - - - - - - - -

From Fight Aging On Increasing Your Chances of Avoiding Alzheimer's July 2011

In many ways, Alzheimer's Disease looks a lot like type 2 diabetes - it can be argued that there are some biochemical similarities in the underlying mechanisms, Alzheimer's appears to be a lifestyle disease to some degree, and the two conditions have many of the same risk factors, such as obesity and being sedentary. So: "Over half of all Alzheimer's disease cases could potentially be prevented through lifestyle changes and treatment or prevention of chronic medical conditions. ...

Analyzing data from studies around the world involving hundreds of thousands of participants, [researchers] concluded that worldwide, the biggest modifiable risk factors for Alzheimer's disease are, in descending order of magnitude, low education, smoking, physical inactivity, depression, mid-life hypertension, diabetes and mid-life obesity. ...
In the United States, [researchers] found that the biggest modifiable risk factors are

  • physical inactivity,
  • depression,
  • smoking,
  • mid-life hypertension,
  • mid-life obesity,
  • low education and
  • diabetes. ...

Note: EVERY SINGLE ONE of the above associations with Alzheimer's Disease is also associated with low vitamin D:

  • physical inactivity - not get out in the sun
  • depression category - a common result of low vitamin D:
  • Smoking - well known to consume vitamin D
  • mid-life hypertension a result of low vitamin D:
  • mid-life obesity - which results from low vitamin D, and Obesity makes vitamin D levels even lower
  • Low education - take far fewer nutritional supplements - due to cost, knowledge, belief
    • Note: low education is also associated with dark skinned people, who get less vitamin D from the sun
  • diabetes - a result of low vitamin D:

Clinical Trials underway for Cognition and Vitamin D INTERVENTION


See also web


Vitamin D, Cognition and Alzheimer's Disease: The Therapeutic Benefit is in the D-Tails - May 2016

J Alzheimers Dis. 2016 May 11;53(2):419-44. doi: 10.3233/JAD-150943.
Landel V1, Annweiler C2,3, Millet P1,4, Morello M1,5,6, Féron F1.
Image
Fig. 2. Proposed mechanisms of vitamin D-mediated multitargeted effects in AD. Vitamin D imbalance is proposed to alter mechanisms implicated in aging and AD pathogenesis. Suggested protective effects of vitamin D supplementation concern regulation of vascular processes and oxidative stress, calcium homeostasis, neurotransmission, modulation of immune and inflammatory processes, and direct impact on amyloidogenesis, ultimately improving cognitive functions.

 Download the PDF from VitaminDWiki


6X increase in Age-Adjusted Death from Dementia (Finland) in 30 years

Age-adjusted = increase is NOT due to having a larger elderly population
Dementia death rate - age standardized @is.gd/increasedisease

Increased incidence Dementia and Alzheimers per 1000 Canadians

Image

  • 2008 paper, Dementia increase appears to be 1.6X per decade - rising to 8 out of every 10 Canadians
  • Note: Canadians have less Vitamin D than those in US, so having higher incidence of a vrtamin D releated disease is understandable
    Other latitude related diseases include Multiple Sclerosis and Cancers
  • Age was not stated in the on-line PDF, Guess it is age > 85

More than half of dark-skinned elderly have Alzheimer's

    See also: dark skin is associated with less Vitamin D

Image

Age-adjusted Death rates: Alzheimer's has been increasing the fastest

Image

Big increase if both parents had Alzheimer's

Image

54% of ALL people, of all ages, are now "touched" by Alzheimer's

Image

Alzheimers Association facts and figures 2016 - nothing about vitamin D

 Download the PDF from VitaminDWiki
Has A LOT of information, including the following

  • "Compared with no TBI, moderate TBI is associated with twice the risk of developing Alzheimer’s and other dementias, and severe TBI with 4.5 times the risk"
  • "1 in 9 people over age 65 has Alzheimer's Disease"
  • "Among people aged 70, 61% of those with Alzheimer's Disease are expected to die before age 80 vs 30% of those without Alzheimers' "
  • "15 million Americans provide unpaid care for people with Alzheimer’s disease and other dementias."
  • "Total payments for Heatlh Care, Long term care, and Hospice are estimated to be $236 billion in 2016 for people with Alzheimer’s disease and other dementias."
    This $236 Billion does NOT include the costs due tor care-giving by family, lost time from work, etc.

Percentage Changes in Selected Causes of Death (All Ages) Between 2000 and 2013

Image

Alzheimer's in more than half of hospital patients over age 65

Image

Half of care-giving for 6+ years is due to Alzheimer's or other dementia

Image

Work changes due to Alzheimer's or Dimentia care-giving

Image


What if we could delay onset of Alzheimer's by 5 years - Alzheimer's Association - 2015

 Download the PDF from VitaminDWiki
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Looks like about half of the people would not have Alzheimer's costs (die sooner?)


Cognition other than Vitamin D monotherapy

Magnesium and Mental Health  see  is.gd/VDMag

Items in BOTH Cognition and Omega-3 categories


APOE4 gene greatly increases risk of AD, but had been a benefit during childhood

The APOe4 gene protected our ancestors and helped them get through the child bearing years by attacking parasites and micro-organisms with oxidative stress. It is only in modern times that people live long enough for the same oxidative stress to work against us in old age.
A book, Survival of the Sickest,(2008) points out roughly the same concept in a number of other diseases which long ago helped our ancestors get through plagues, ice ages, parasites, famine, etc. It's a fascinating concept and it makes sense. By Rich H, Jan 2017
 Download the PDF of the book from VitaminDWiki


Small amount of Lithium slowed dementia in Alzheimer's

Rate of a rare form of Alzheimer's is increased if exposed to lots of Aluminium - 2017


short url = http://is.gd/dcognition

Alzheimers-Cognition - Overview        

43183 visitors, last modified 27 Apr, 2017, URL:

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Attached files

ID Name Comment Uploaded Size Downloads
7796 ALZ Fig 2.jpg admin 05 Mar, 2017 22:00 21.45 Kb 695
7795 Therapeutic Benefit is in the D-Tails.pdf PDF 2016 admin 05 Mar, 2017 21:59 523.25 Kb 96
7627 Survival Of The Sickest - 2008 book.pdf PDF admin 06 Jan, 2017 22:52 947.50 Kb 297
7553 Lithium to the Rescue.pdf PDF 2016 admin 23 Dec, 2016 12:18 670.40 Kb 335
7407 Lithium as Nutrient - 2015.pdf PDF 2015 admin 29 Nov, 2016 11:40 128.16 Kb 213
7406 Lithium and Alz LEF Dec 2016.pdf PDF 2016 admin 28 Nov, 2016 23:56 3.40 Mb 266
7256 If delay onset by 5 years.jpg admin 29 Oct, 2016 14:54 15.97 Kb 1223
7255 Delay Alz by 5 years - 2015.pdf PDF 2015 admin 29 Oct, 2016 14:50 1,015.63 Kb 407
7254 Work changes due to Alz or Dimentia care-giving.jpg admin 29 Oct, 2016 14:12 19.54 Kb 1346
7253 Half of care giving for 6+ years is due to Alzheimer's or other dementia.jpg admin 29 Oct, 2016 14:06 38.45 Kb 1245
7252 Percentage Changes in Selected Causes of Death (All Ages) Between 2000 and 2013.jpg admin 29 Oct, 2016 00:04 21.84 Kb 1290
7251 Alz in more than half of hospital patients over age 65.jpg admin 28 Oct, 2016 23:46 37.59 Kb 1432
7250 Alzheimers Association facts and figures 2016.pdf PDF 2016 admin 28 Oct, 2016 23:45 2.07 Mb 359
7249 Alzheimer's dark skin.jpg admin 28 Oct, 2016 21:22 23.01 Kb 1300
7248 54% touched by Alzheimer's.jpg admin 28 Oct, 2016 21:21 23.94 Kb 1291
7247 Alzheimer's both parents.jpg admin 28 Oct, 2016 21:21 31.71 Kb 1294
4867 Dementia incidence.jpg admin 12 Jan, 2015 02:24 61.75 Kb 6338
4095 Alz nutrient status.pdf PDF 2014 admin 29 Jun, 2014 10:54 1.57 Mb 1177
3475 Death rates alzheimers.gif admin 02 Jan, 2014 17:37 38.58 Kb 11575
3469 Alzheimers percentage.png admin 29 Dec, 2013 11:57 49.40 Kb 22763
1131 Alzheimer\'s 2011.pdf PDF admin 04 Mar, 2012 15:28 1.09 Mb 1637
1130 Alz in hospital - 2011.jpg Go to hospital with Alz admin 04 Mar, 2012 15:24 34.72 Kb 9008
1129 Alz how long - 2011.jpg how long care needed admin 04 Mar, 2012 15:23 28.67 Kb 8661
1128 Alz F5 - 2011.jpg increases admin 04 Mar, 2012 15:23 20.73 Kb 8876
1120 Potential targets for Alz.jpg targets from D-Mentia admin 26 Feb, 2012 21:01 21.24 Kb 11086
1119 Vitamin D-mentia.pdf admin 26 Feb, 2012 21:00 292.71 Kb 1945
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