Maternal/neonatal vitamin D deficiency: a risk factor for bronchopulmonary dysplasia in preterms?
J Perinatol. 2015 Jul 30. doi: 10.1038/jp.2015.88. [Epub ahead of print]
Çetinkaya M1, Çekmez F2, Erener-Ercan T1, Buyukkale G1, Demirhan A3, Aydemir G4, Aydin FN5.
1Kanuni Sultan Suleyman Teaching and Research Hospital, Department of Neonatology, Istanbul, Turkey.
2Gulhane Military Medical Faculty, Department of Neonatology, Istanbul, Turkey.
3Kanuni Sultan Suleyman Teaching and Research Hospital, Department of Pediatrics, Istanbul, Turkey.
4Gulhane Military Medical Faculty, Department of Pediatrics, Istanbul, Turkey.
5Gulhane Military Medical Faculty, Department of Biochemistry, Ankara, Turkey.
The objective of this study was to investigate the possible association between maternal/neonatal 25-hydroxy vitamin D (25-OHD) levels and development of bronchopulmonary dysplasia.
One hundred and thirty-two preterm infants < 32 weeks of gestation who were diagnosed with respiratory distress syndrome were enrolled. 25-OHD levels were determined in maternal/neonatal blood samples that were obtained at the time of admission to the neonatal intensive care unit.
A total of 100 infants were included and 31 (31%) developed bronchopulmonary dysplasia (BPD). Both maternal and neonatal 25-OHD levels in the BPD group were significantly lower compared with those in the no-BPD group (P=0.0001). A positive correlation was detected between maternal and neonatal 25-OHD levels. All of the infants with BPD had a 25-OHD level <10 ng ml-1, which represented severe deficiency. Univariate logistic regression analysis revealed that maternal/neonatal vitamin D levels were a significant predictor of BPD (odds ratio (OR): 0.76 and 0.61, respectively, P<0.001).
We demonstrated for the first time that lower maternal and neonatal vitamin 25-OHD levels were associated with BPD development in preterm infants. However, further studies with larger sample sizes are needed to delineate the possible link between vitamin D deficiency and BPD.
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