HIGH PREVALENCE OF VITAMIN D DEFICIENCY AND ADVERSE PREGNANCY OUTCOMES IN YAZD, A CENTRAL PROVINCE OF IRAN
JOURNAL OF REPRODUCTION AND INFERTILITY JAN-MARCH 2016 , Vol 17 , # 1; Page(s) 34 To 38.
ONCHIETTI ROBERTO*, VAKILI MAHMOOD, DEHGHANI REYHANEH, ZARE FATEMEH
*DEPARTMENT OF COMMUNITY AND PREVENTIVE MEDICINE, SCHOOL OF MEDICINE, HAMADAN UNIVERSITY OF MEDICAL SCIENCES, HAMADAN, IRAN
|6.5%||premature rupture of membrane,|
Background: There is a growing concern about the high prevalence of vitamin D deficiency and its relationship with variety of diseases worldwide. The objective of this study was to determine the prevalence of vitamin D deficiency and its relationship with pregnancy adverse effects in Yazd.
Methods: This was a cross sectional study conducted among 200 nulliparous women from October 2013 to April 2014. Data containing socio-demographic and personal details, vitamin D level, pregnancy complications and growth situation of newborns were collected and analyzed using Mann-Whitney, Kruskal-Wallis and Pearson’s correlation coefficient by SPSS. p<0.05 was considered statistically significant.
Results: The mean serum 1, 25 (OH)2D3 concentration was 20.3±10.8 mg/l. Totally, 78% of the women had less than sufficient levels. Mean of vitamin D was significantly higher in natural or elective cesarean in comparison with abortion and emergency cesarean (p=0.040). Risk of abortion was 3.1 (1.39-6.8) and higher in severely deficient group in comparison to women with vitamin D deficiency (p=0.017) and mean of vitamin D group was significantly lower in women who had oligohydramnios or polyhydramnios complication (p=0.045).
Conclusion: The study findings revealed that vitamin D deficiency is prevalent in pregnant women and it is significantly associated with elevated risk for abortion, and oligohydramnios or polyhydramnios. Probably, a targeted screening strategy can be suggested to detect and treat women at high risk of vitamin D deficiency in early pregnancy as a simple way to reduce the risk of these adverse pregnancy outcomes in Yazd.
See also VitaminDWiki
- Recurrent spontaneous abortions associated with low vitamin D levels – Nov 2013
- Overview Autism and vitamin D
include: HYPOTHESIS Folate ==> reduced miscarriage ==> increased autism
- Smoking while pregnant: are the problems due to low vitamin D – July 2013
Smoking (==> reduces vitamin D) ==> increases miscarriage
- Miscarriage in first trimester 2.5X more likely if less than 20 ng of vitamin D – July 2015
- Miscarriage 70 percent more likely if low vitamin D (see also data on CYP27B1) – May 2016
Pregnancy category starts with
- see also
- Overview Pregnancy and vitamin D
- Healthy pregnancies need lots of vitamin D
- Dark skin births are much riskier due to lack of vitamin D,
- All items in category Infant/Child
- breastfed 887 items as of Feb 2017
- Preeclampsia 949 items as of Feb 2017
- Pre-term 2110 items as of Feb 2017
- "polycystic ovary syndrome" OR PCOS 298 items as of Feb 2017
- Gestational Diabetes
- c-section OR "caesarean section" (various spellings) 242 items as of Feb 2017
- postpartum depression 36 items as of April 2016
- Search VitaminDiiki for MISCARRIAGE OR "Spontaneous abortion" 339 items as of Jan 2018
- Search VitaminDWiki for "Assisted reproduction" 33 items as of Feb 2017
- (Stunting OR “low birth weight” OR LBW) 505 items as of Jan 2018
- Click on chart for details
Healthy pregnancies need lots of vitamin D has the following summaryProblem
Reduces Proof 1. Miscarriage 2.5 times Observe 2. Pre-eclampsia 3.6 times RCT* 3. Gestational Diabetes 3 times RCT* 4. Good 2nd trimester sleep quality 3.5 times Observe 5. Premature birth 2 times RCT* 6. C-section - unplanned 1.6 times Observe 7. Depression AFTER pregnancy 1.4 times RCT* 8. Small for Gestational Age 1.6 times meta-analysis 9. Infant height, weight, head size
within normal limits
RCT* 10. Childhood Wheezing 1.3 times RCT* 11. Additional child is Autistic 4 times Intervention 12.Young adult Multiple Sclerosis 1.9 times Observe 13. Preeclampsia in young adult 3.5 times RCT* 14. Good motor skills @ age 3 1.4 times Observe 15. Childhood Mite allergy 5 times RCT* 16. Childhood Respiratory Tract visits 2.5 times RCT* 1405 visitors, last modified 12 Jun, 2016, URL: