Acetaminophen use in pregnancy and neurodevelopment: attention function and autism spectrum symptoms.
Int J Epidemiol. 2016 Dec 1;45(6):1987-1996. doi: 10.1093/ije/dyw115.
Avella-Garcia CB1,2,3,4,5, Julvez J1,3,6, Fortuny J7, Rebordosa C7, García-Esteban R1,3,6, Galán IR8, Tardón A6,9, Rodríguez-Bernal CL10, Iñiguez C10, Andiarena A11,12, Santa-Marina L6,12,13, Sunyer J1,3,4,5.
It appears the Tylenol (Acetaminophen) injures the liver such that there is less Vitamin D in the bloodstream
- Tylenol associated with both low vitamin D and Autism
with comments by Dr. Cannell
- Acetaminophen (Tylenol) increases asthma
- ADHD and Vitamin D Deficiency 22 items as of June 2017
- Autism treated by Vitamin D: Dr. Cannell - video June 2013
Acetaminophen is extensively used during pregnancy. But there is a lack of population-representative cohort studies evaluating its effects on a range of neuropsychological and behavioural endpoints. We aimed to assess whether prenatal exposure to acetaminophen is adversely associated with neurodevelopmental outcomes at 1 and 5 years of age.
This Spanish birth cohort study included 2644 mother-child pairs recruited during pregnancy. The proportion of liveborn participants evaluated at 1 and 5 years was 88.8% and 79.9%, respectively. Use of acetaminophen was evaluated prospectively in two structured interviews. Ever/never use and frequency of use (never, sporadic, persistent) were measured. Main neurodevelopment outcomes were assessed using Childhood Autism Spectrum Test (CAST), Conner's Kiddie Continuous Performance Test (K-CPT) and ADHD-DSM-IV form list. Regression models were adjusted for social determinants and co-morbidities.
Over 40% of mothers reported using acetaminophen. Ever-exposed offspring had higher risks of presenting more hyperactivity/impulsivity symptoms [incidence rate ratio (IRR) = 1.41, 95% confidence interval (CI) 1.01-1.98), K-CPT commission errors (IRR = 1.10, 1.03-1.17), and lower detectability scores (coefficient β = -0.75, -0.13--0.02). CAST scores were increased in ever-exposed males (β = 0.63, 0.09-1.18).
Increased effect sizes of risks by frequency of use were observed for hyperactivity/impulsivity symptoms (IRR = 2.01, 0.95-4.24) in all children, K-CPT commission errors (IRR = 1.32, 1.05-1.66) and detectability (β = -0.18, -0.36-0.00) in females, and CAST scores in males (β = 1.91, 0.44-3.38).
Prenatal acetaminophen exposure was associated with a greater number of autism spectrum symptoms in males and showed adverse effects on attention-related outcomes for both genders. These associations seem to be dependent on the frequency of exposure.
PMID: 27353198 DOI: 10.1093/ije/dyw115
Study - with details on Autism, is behind a publisher paywall
From the web
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TYLENOL® with Codeine, Tylox, Ultracet, Vicodin, Zydone®
- " , , , it's estimated that approximately 100,000 deaths per year occur from acetaminophen usage. (3) If this were a food or supplement, it would likely be considered quite dangerous, maybe even too dangerous to be sold without a prescription!"
- "And Tylenol use is one of the MAIN CAUSES of non alcoholic liver failure in the US! In fact, among all drugs sold in the US, it is the Number 2 drug that most often causes liver problems (4)."
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Is it safe to take Tylenol during pregnancy?
Acetaminophen is the main ingredient in Tylenol and many other pain medicines. It's often one of the only pain relievers doctors recommend to pregnant women for pain or fever. It's long been viewed as safe during pregnancy and is used by a large number of pregnant women in the U.S. and abroad.Aug 17, 2016
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Taking acetaminophen (used for pain relief) during the first trimester of pregnancy did not appear to increase the risk of major birth defects. Also, taking acetaminophen might decrease the risk of some birth defects in the baby when a pregnant woman uses it to treat a fever.May 5, 2016
- "In fact, because fevers during pregnancy can cause many risks to the developing baby, doctors recommend that you take acetaminophen if your fever is 101 degrees Fahrenheit or higher."
- "It's fine to take either regular or extra strength acetaminophen, but be careful not to take more than the amount recommended on the label. If you take too much, it can cause liver failure both in you and, later in pregnancy, in your baby."
One of the first Tylenol lawsuits $8.8 million
Lawsuits and class-action lawsuits continue thru 2017
- No apparent change by the FDA other than to reduce the maximum strength pill and put a black box warning on Tylenol, but apparently noton the 600 other medicines containing acetaminophen
~ Note: It is extremely easy for a person to take more than one pill