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95 new vitamin D INTERVENTION trials added during 2012

World Health Organization - International Clinical Trials New Registrations

There will be a delay of many years till the results are published.

Expect that many of the trials will not show a benefit for one or more of the following reasons

  1. Not enough vitamin D3 was used in the trial - (much more is typically needed for treatment than for prevention)
  2. Too long of time between doses ( > 3 month between doses)
  3. Trial period too short, or failed to give loading dose. Especially important in groups at high risk of being vitamin D deficient
  4. Vitamin D2 was used, rather than D3
  5. Cofactor was needed - vitamin D monotheraphy is not always a good thing
  6. Vitamin A (or cod liver oil) inhibited the vitamin D dose
  7. The group was known to have mal-absorption problems - so a different vitamin D should have been used
  8. Individuals were using drugs which are known to inhibit vitamin D
  9. Participants had low compliance (people tend to forget to take the pill in trials which run for years, easy to remember if it is on the calendar)
  10. Participants already have enough Vitamin D and adding more does not provide any additional benefit - example RCT of colds Oct 2012

NCT01655966 Vitamin D as an add-on Therapy With Pegylated Interferon and Ribavirin for Chronic Hepatitis c 31/07/2012
NCT01656512 Zometa Study in Pediatric Acute Lymphoblastic Leukemia 30/07/2012
NCT01653678 Vitamin D and Omega-3 Hypertension Trial (VITAL Hypertension) 27/07/2012
ACTRN12612000787886 The effects of vitamin D supplementation in infancy on immune development 25/07/2012
NCT01650883 A Prospective Open-label Comparison of Two Vitamin D3 Repletion Strategies in Vitamin D Deficient Patients 23/07/2012
NCT01655810 Vitamin D, Cardiovascular Disease, and African Americans 19/07/2012
ISRCTN99745836 A comparison of the absorption of Vitamin D with and without pollen 16/07/2012
CTRI/2012/07/002799 Effect of vitamin B12 fortified nutrient bar supplementation in Indian children 16-07-2012
CTRI/2012/07/002792 vitamin D and calcium Supplementation reduces the complication of letrozole in breast cancer patients 12-07-2012
NCT01640496 Vitamin D Treatment in Ulcerative Colitis 11/07/2012
NCT01637155 Study to Evaluate the Pharmacokinetics of Vitamin D (Cholecalciferol) in Patients Undergoing Obesity Surgery in a Deficit Situation and After Standardization 10/07/2012
NCT01646437 The International Polycap Study 3 (TIPS-3) 10/07/2012
NCT01640184 Efficacy and Safety of Ultrasonic Ablation to Treat Secondary Hyperthyroidism in Chronic Kidney Disease Patients 09/07/2012
NCT01639222 Human Pharmacology Trial of Calcium-vitamin D3 Tablet in Healthy Participants 09/07/2012
JPRN-UMIN000008361 Multicenter, randomized, double-blind, placebo controlled, parallel group trial to evaluate the effect of Vitamin D supplementation for fall prevention 06/07/2012
ACTRN12612000714886 Effect of vitamin D supplementation on glucose control and inflammatory response in type II diabetic patients. 04/07/2012
NCT01633658 The Variability of 25-hydroxyvitamin D Response From Crystalline 25-hydroxyvitamin D3 02/07/2012
NCT01633853 Efficacy of Vitamin D2 to Treat Chronic Kidney Disease Mineral and Bone Disorder 29/06/2012
NCT01631526 Vitamin D Loading Dose in Advanced Lung Cancer 27/06/2012
NCT01633177 Study of Vitamin D and Omega-3 Supplementation for Preventing Diabetes 26/06/2012
NCT01630213 Impact of Vitamin D Supplementation on Cardiac Structure and Function 25/06/2012
IRCT201205319919N1 The effect of vitamin D in Optic Neuritis outcome 2012-06-23
NCT01623024 Effect on Liver Histology of Vitamin D in Patients With Non-alcoholic Steatohepatitis 15/06/2012
CTRI/2012/06/002728 Effects of Vitamin E and C and Tulsi on blood glucose and serum lipids in diabetic and Hypertensive Patients. 14-06-2012
NCT01619891 VitamIN D Treating patIents With Chronic heart failure 12/06/2012
IRCT201112068307N1 Evaluation of vitamin D3 Supplementation on Serum Level of P-selectin and hs-CRP 2012-06-12
IRCT201202189056N1 Studies on the possible lowering of occupational errors by intervention on inflammatory , oxidative stress factors and depression in Tehran refinery oil shift workers treated with omega 3 and vitamin C. 2012-06-05
ACTRN12612000592842 Neural adaptations to vitamin D supplementation in older adults: A pilot study 01/06/2012
IRCT201111082709N22 the effect of symbiotic on treatment of fatty liver 2012-05-29
ACTRN12612000570886 Vitamin D in the management of Childhood Atopic Dermatitis (eczema) 28/05/2012
ACTRN12612000560897 Vitamin D therapy in patients with sickle cell disease (SCD) 25/05/2012
NCT01609439 Preoperative Vitamin D for Post-thyroidectomy Hypocalcemia 24/05/2012
NCT01608451 Progesterone and Vitamin D3 in Women With LOBC and LABC - A Feasibility Study 22/05/2012
NCT01601847 Wheezing in Black Preterm Infants: Impact of Vitamin D Supplementation Strategy 16/05/2012
NCT01600430 Vitamin D Supplementation for Extremely Preterm Infants 14/05/2012
NCT01597765 Effect of Antioxidant Cocktail in Beta-thalassemia/Hb E Patients 10/05/2012
NCT01596842 Effect of Omega-3 Fatty Acid on Vitamin D Activation 08/05/2012
ACTRN12612000497808 Efficacy of vitamin A and zinc supplementation on pathogen-specific diarrheal disease. 08/05/2012
NCT01593501 How Does Magnesium Status Influence Calcium Homeostasis? 04/05/2012
CTRI/2012/05/002621 Appropriate dose of Vitamin-D for treatment of Vitamin-D deficiency 01-05-2012
ISRCTN38158659 Vitamin D supplementation in the obese 27/04/2012
JPRN-UMIN000007853 Associations between serum vitamin D Level with physical activity and cardiorespiratory fitness in healthy adults 27/04/2012
NCT01595893 Vitamin D Supplementation in Polymorphic Light Eruption 26/04/2012
IRCT201201072394N6 Effect of vitamin D in major depression 2012-04-25
ChiCTR-TRC-12002116 A multi-center randomized controlled clinical trial on treatment of chronic hepatitis C using Vitamin D combine pegylated interferon + ribavirin 2012-04-24
NCT01585051 Effect of Vitamin D Supplementation on Blood Pressure and HbA1c Levels in Patients With T2D 23/04/2012
ACTRN12612000452897 Effect of vitamin D supplements on cardiometabolic risk and quality of life in premenopausal women: a randomized control trial 23/04/2012
NCT01588795 Renal Denervation in Diabetic Nephropathy 18/04/2012
NCT01580007 Clinical Trial of Phenylbutyrate and Vitamin D in Tuberculosis (TB) 17/04/2012
KCT0000406 The effect of vitamin D on the glycemic control and non-alcoholic fatty liver disease 17/04/2012
NCT01577849 Safety and Pharmacokinetic Characteristics of DP-R206(Vitamin D3) in Healthy Adult Volunteers 13/04/2012
ISRCTN07034656 Biochemical Efficacy and Safety Trial of vitamin D (BEST-D) 12/04/2012
NCT01578473 Testosterone Pellets Plus Vitamin D and E Versus Vitamin D and E Alone for the Treatment of Peyronie's Disease 12/04/2012
NCT01578434 Role of Calcium And Vitamin D In Nutritional Rickets And It's Management 12/04/2012
NCT01575717 The Effect of Vitamin D Repletion in Patients With Hepatocellular Carcinoma on the Orthotopic Liver Transplant List 09/04/2012
NCT01583621 Vitamin D Supplementation in Overweight/Obese African American Adults and Youth (D-SUNNY) 03/04/2012
ACTRN12612000374864 Calcium and vitamin-D supplementation on bone structural properties in young male Jockeys: A RCT. 02/04/2012
NCT01568255 Is Treatment of Vitamin D Deficiency Associated With Resolution of Statin-Induced Muscular Symptoms 29/03/2012
NCT01571063 Treatment of Non-alcoholic Steatohepatitis (NASH) Patients With Vitamin D 28/03/2012
NCT01570309 Vitamin D Repletion in Coronary Artery Disease 26/03/2012
ACTRN12612000334808 The Swinburne Multivitamin Study: The Effects of Multivitamin Supplementation on mood, stress and brain function in older adults 22/03/2012
ACTRN12612000329864 The effect of high calcium vitamin D fortified milk drink on biochemical markers of bone turnover, vitamin D levels and parathyroid hormone levels in post-menopausal Chinese women. 22/03/2012
NCT01561989 Cholecalciferol and Flu Vaccine in Treating Healthy Participants 16/03/2012
Authorised EUCTR2011-000593-54-IT Effect of Vitamin D supplementation in HIV-infected children, adolescents and young adults with hypovitaminosis D. 13/03/2012
NCT01554241 Optimizing Vitamin D in the Elderly 12/03/2012
IRCT201201258820N1 Therapeutic effects of vitamin D3 in women with recurrent spontaneous abortion 2012-03-12
NCT01552122 Efficacy and Safety of Odanacatib in Postmenopausal Women Previously Treated With Alendronate (MK-0822-050) 09/03/2012
Authorised EUCTR2012-000300-15-AT Vitamin D supplementation in polymorphic light eruption: Randomized double-blinded placebo-controlled trial - Vitamin D and PLE 06/03/2012
Authorised EUCTR2011-006163-22-ES Study to evaluate the pharmacokinetic of vitamin D in patients with obesity after bariatric surgery 06/03/2012
JPRN-UMIN000007400 The efficacy and safety analysis of Peg-IFN/RBV/Vitamin D3 therapy for liver cirrhosis with hepatitis c persistent infection: RCT Study 01/03/2012
DRKS00003561 Study to evaluate the therapy of pigmented purpura progressiva with rutin and vitamin c - a retrospective study 29/02/2012
JPRN-UMIN000007398 Effect of Bazedoxifene to osteoporotic patients under active vitamin D treatment 28/02/2012
NCT01545830 Metabolic Syndrome and Insulin Resistance at Allina 28/02/2012
NCT01544101 A Nutritional Intervention for Arthritis 27/02/2012
CTRI/2012/02/002459 Efficacy of Different Regimens of Vitamin D Supplementation in Preterm Infants - A Randomized Double Blind Trial 27-02-2012
IRCT201107237097N1 The effect of 50000 IU Vitamin D supplement administered two weekly on gestational Diabetes Melitus 2012-02-27
ACTRN12612000207819 Therapeutic Approaches to Nutrition in Ataxia-Telangiectasia: a Randomised Controlled Matched Cross-over Trial 20/02/2012
NCT01537809 Impact of Vitamin D Supplementation on Cardiometabolic Risk Factors [The Daily D Health Study] 17/02/2012
CTRI/2012/02/002429 Vitamin D fortified milk supplementation in school children 16-02-2012
ACTRN12612000189820 A crossover, placebo-controlled trial to determine the impact of independent and combined alcohol and energy drink consumption on risky and impulsive behaviour 14/02/2012
NCT01535508 Open Label Clinical Trial of Vitamin D in Children With Autism 14/02/2012
Authorised EUCTR2011-002162-21-ES Study on the effect of vitamin D in women at high risk of developing breast cancer. 10/02/2012
NCT01538485 Vitamin D Supplementation and Regulatory FoxP3+ T Cells in the GUT 08/02/2012
ChiCTR-TRC-12001914 Effects of Vitamin A Supplementation to Lactating Mothers on Infants’ Antibody Response to Hepatitis B Vaccine in China 2012-02-04
IRCT201111158109N1 The effect of Vitamin D vagi on vaginal atrophy 2012-02-04
NCT01528176 Vitamin D Metabolism in Chronic Kidney Disease Patients 03/02/2012
CTRI/2012/02/002395 Vitamin D supplementation in pregnancy: regimens and long term effects on offspring 01-02-2012
RBR-95j5pm Effects of supplementation with vitamin D in patients with chronic kidney disease 30/01/2012
NCT01523496 Vitamin D Supplementation in HIV Youth 27/01/2012
NCT01521936 Cholecalciferol in Treating Patients With Acute Myeloid Leukemia Undergoing Intensive Induction Chemotherapy 26/01/2012
ACTRN12612000098831 DNA damage and Nutritional Profile of ApoE4 carriers, the Major Genetic Risk Factor for Alzheimer’s Disease 20/01/2012
NCT01518725 The Effect of Vitamin D Supplementation on Muscle Power in Elite Cyclist 18/01/2012
ISRCTN21527585 Effect of vitamin D treatment on the improvement of metabolic syndrome 16/01/2012
NCT01516216 Study of Vitamin D in Untreated Metastatic Colorectal Cancer 13/01/2012
ACTRN12612000054819 Cholecalciferol (Vitamin D) Intervention to Prevent Respiratory Infection Study 11/01/2012
ACTRN12612000031864 Vitamin D and muscle strength in female dancers and gymnasts 09/01/2012
NCT01508845 A Pilot Study of the Effect of Dietary Fat Type and Amount on Vitamin D3 Absorption 09/01/2012
NCT01518959 The Effect of 25-OH-Vitamin-D3 Substitution in Patients With Malignant and Immune-hematologic Diseases 06/01/2012
NCT01519986 The Effect of Fat on Vitamin D Absorption 05/01/2012
NCT01546103 Vitamin D3 Supplementation Pilot Study 04/01/2012
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See also VitaminDWiki

All cause mortality
Atopic dermatitis
Bone loss in winter
Breast cancer
Colorectal cancer
Cancer, All
Cardiometric
Cardiovascular
Cardiovascular disease event
Chronic kidney disease
CVD survival
Depression
Falls
Falls, fractures
Gastric bypass
Glucose (fasting plasma) (FPG)
Haemodialysis
Heart failure, congestive
Infections, symptomatic upper respiratory tract
Infectious diseases
Influenza
Influenza type A
Insulin sensitivity
Multiple sclerosis
Muscle strength
Musculoskeletal parameters
Neuromuscular
Non-vertebrate fractures
Physical performance
Pneumonia
Pregnancy
Stress fractures
Testosterone
Tooth loss
Tuberculosis

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