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Vitamin D Deficiency in Alopecia Areata.
Br J Dermatol. 2014 Mar 21. doi: 10.1111/bjd.12980. [Epub ahead of print]
Aksu Cerman A1, Sarikaya Solak S, Kivanc Altunay I.
Şişli Etfal Training and Research Hospital, Dermatology Department.
Alopecia areata is a T-cell mediated autoimmune disease that causes inflammation around anagen-stage hair follicles. Deficient vitamin D levels have been implicated in patients with a variety of autoimmune diseases in recent years. Previous reports have described the effects of vitamin D on hair follicles.
The aim of the study was to evaluate the status of vitamin D in patients with alopecia areata and the relationship between vitamin D levels and disease severity.
A cross-sectional study was conducted of 86 patients with alopecia areata, 44 patients with vitiligo, and 58 healthy controls. Serum vitamin D levels of the study group were determined by liquid chromatography/tandem mass spectrometry.
Serum 25(OH)D levels in patients with alopecia areata were significantly lower than those of the patients with vitiligo and the healthy controls (P= 0.001 and P<0.001, respectively). The prevalence of 25(OH)D deficiency was significantly higher in the patients with alopecia areata (90.7%) compared with the patients with vitiligo (70.5%) and the healthy controls (32.8%) (P= 0.003 and P<0.001, respectively). Furthermore, a significant inverse correlation was found between disease severity and serum 25(OH)D level in the patients with alopecia areata (r= - 0.409; P<0.001).
Deficient serum 25(OH)D levels are present in alopecia areata patients and inversely correlate with disease severity.
Accordingly, screening alopecia areata patients for vitamin D deficiency seems to be of value for the possibility of vitamin D supplementation.
Spot baldness strongly associated with low vitamin D levels – June 2014
Association between vitamin D levels and alopecia areata.
Isr Med Assoc J. 2014 Jun;16(6):367-70.
Mahamid M, Abu-Elhija O, Samamra M, Mahamid A, Nseir W.
BACKGROUND: Alopecia areata (AA) is an autoimmune disease, based on the response to local and/or systemic corticosteroid treatment. The role of vitamin D in the pathogenesis of immune/autoimmune mediated diseases has been widely studied.
OBJECTIVES: To investigate a possible association between serum 25-hydroxyvitamin D levels and alopecia areata.
METHODS: The study included 23 patients diagnosed with AA followed at our outpatient clinic during the period March 2010 to May 2011, as well as a control group matched for age and gender. All subjects underwent a complete work-up and medical examination, anthropometric measurements and laboratory tests. Laboratory tests included complete blood count, C-reactive protein (CRP), and vitamin D levels.
RESULTS: Mean CRP values were significantly higher in the AA group than the control group (1.1 +/- 0.7 mg/dl vs. 0.4 +/- 0.8 mg/ dl, P < 0.05). Vitamin D levels were significantly decreased in the AA group (11.32 +/- 10.18 ng/ml vs. 21.55 +/- 13.62 ng/ml in the control group, P < 0.05). Multivariate analysis showed that CRP (odds ratio 3.1, 95% confidence interval 2.6-4.2, P = 0.04) and serum vitamin D levels < 30 ng/ml (OR 2.3, 95% CI 2.2-3.1, P = 0.02) were associated with AA.
CONCLUSIONS: We found a significant correlation between AA and vitamin D deficiency.
Vitamin D deficiency can be a significant risk factor for AA occurrence.
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Apparently 1 - 2 people in 1,000 have alopecia areata
AA had 13.5 ng, healthy controls had 22.5 ng.
See also VitaminDWiki
- Search VitaminDWiki for alopecia areata 22 items as of March 2017
- Health problems that run in families are often associated with low vitamin D
- Topical Vitamin D uses – Review March 2014 evidence does not show that vitamin D deals with alopecia areata
- Vitamin D reduces hair loss
See also web
Reduced level of 25-hydroxyvitamin D in chronic/relapsing Alopecia Areata.
Dermatoendocrinol. 2013 Apr 1;5(2):271-3. doi: 10.4161/derm.24411. Epub 2013 Jan 1.
d'Ovidio R1, Vessio M, d'Ovidio FD.
Current observations link vitamin D deficiency to many autoimmune diseases. There are limited data on vitamin D in Alopecia Areata, an autoimmune disease which in our experience shows seasonality in most of its remitting-relapsing forms. Our results demonstrate the presence of insufficiency of 25-hydroxyvitamin D (25OH-D) in many patients with various clinical forms, correlated with the expected increase of the values of Parathyroid Hormone (PTH). This could suggest the possible clinical use of vitamin D in the management of this frustrating disease.