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5000 to 10000 IU vitamin D helped MS in a pilot study – March 2012

A pilot study of the immunological effects of high-dose vitamin D in healthy volunteers.

Mult Scler. 2012 Mar 28.
Allen AC, Kelly S, Basdeo SA, Kinsella K, Mulready KJ, Mills KH, Tubridy N, Walsh C, Brady JJ, Hutchinson M, Fletcher JM.
School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland.

Although vitamin D deficiency is considered an environmental factor in multiple sclerosis (MS), the immunological and clinical effects of vitamin D supplementation remain unclear.

We performed a pilot study of the immunomodulatory effects of vitamin D in healthy individuals (n=4), who took 5000-10,000 IU/day of vitamin D over 15 weeks.

After 15 weeks of vitamin D supplementation, serum 25(OH) vitamin D

  • levels rose significantly from baseline, with a
  • corresponding increase in IL-10 production by peripheral blood mononuclear cells and a
  • reduced frequency of Th17 cells.

These data provide a strong rationale for randomised trials to assess the clinical effects of vitamin D supplementation in MS.

PMID: 22457344