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2000 IU of vitamin D should improve toddlers health in winter – RCT almost completed Feb 2014

Update July 2017:
2,000 IU did not reduce the number of infections during the entire 4 month trial

JAMA
VitaminDWiki suspects that only a few of the children achieved a good level of vitamin D by the 4th month
The trial, however. appears to have measured the amount of infections during the entire time, not just the last month
Since the infections during the entire 4 months were not reduced, vitamin D did not help.
JAMA charges to see the PDF


DO IT Trial: vitamin D Outcomes and Interventions in Toddlers
- a TARGet Kids! randomized controlled trial.

BMC Pediatr. 2014 Feb 8;14(1):37.
Maguire JL, Birken CS, Loeb MB, Mamdani M, Thorpe K, Hoch JS, Mazzulli T, Borkhoff CM, Macarthur C, Parkin PC.

BACKGROUND:
Vitamin D levels are alarmingly low (<75 nmol/L) in 65-70% of North American children older than 1 year. An increased risk of viral upper respiratory tract infections (URTI), asthma-related hospitalizations and use of anti-inflammatory medication have all been linked with low vitamin D. No study has determined whether wintertime vitamin D supplementation can reduce the risk of URTI and asthma exacerbations, two of the most common and costly illnesses of early childhood. The objectives of this study are: 1) to compare the effect of 'high dose' (2000 IU/day) vs. 'standard dose' (400 IU/day) vitamin D supplementation in achieving reductions in laboratory confirmed URTI and asthma exacerbations during the winter in preschool-aged Canadian children; and 2) to assess the effect of 'high dose' vitamin D supplementation on vitamin D serum levels and specific viruses that cause URTI.

Methods/design: This study is a pragmatic randomized controlled trial. Over 3 successive winters we will recruit 750 healthy children 1-5 years of age. Participating physicians are part of a primary healthcare research network called TARGet Kids! Children will be randomized to the 'standard dose' or 'high dose' oral supplemental vitamin D for a minimum of 4 months (200 children per group). Parents will obtain a nasal swab from their child with each URTI, report the number of asthma exacerbations and complete symptom checklists. Unscheduled physician visits for URTIs and asthma exacerbations will be recorded. By May, a blood sample will be drawn to determine vitamin D serum levels. The primary analysis will be a comparison of URTI rate between study groups using a Poisson regression model. Secondary analyses will compare vitamin D serum levels, asthma exacerbations and the frequency of specific viral agents between groups.

DISCUSSION:
Identifying whether vitamin D supplementation of preschoolers can reduce wintertime viral URTIs and asthma exacerbations and what dose is optimal may reduce population wide morbidity and associated health care and societal costs. This information will assist in determining practice and health policy recommendations related to vitamin D supplementation in healthy Canadian preschoolers and place Canada at the forefront of pediatric vitamin D health outcomes research.

PMID: 24506910


Clinical Trial NCT01419262

Study First Received: August 2011
Estimated Primary Completion Date: May 2014
Estimated Study Completion Date: September 2014

PDF is attached at the bottom of this page

Rough HTML of the study is at the end of this page

A tiny number of people get even the "minimum wage" of vitamin D (orange line)

Only about 20% of kids normally get 600 IU per day

from Dietary Guidelines for Americans vitamin D - June 2010

VitaminDWiki opinion

Anticipate great success from this Random Controlled Trial based on scores of previous studies

See also VitaminDWiki

Image

Attached files

ID Name Comment Uploaded Size Downloads
3612 2000 IU RCT started.pdf PDF 2014 admin 12 Feb, 2014 10:21 559.67 Kb 1016
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