Outcomes with perioperative fat emulsions containing omega-3 fatty acid: A meta-analysis of randomized controlled trials
American Journal of Health-System Pharmacy June 2017, 74 (12) 904-918; https://doi.org/10.2146/ajhp151015
Hye Jung Bae, Gwan Young Lee, Jong-Mi Seong and Hye Sun Gwak
Perioperative care is the care that is given before, during and after surgery
Omega-3 and Inflammation (items in both categories)
- Vitamin D deficiency with severe sepsis increased risk of dying by 7.7 X – Nov 2017
- Severe sepsis may be prevented by 400,000 IU of vitamin D – RCT 2023
- Sepsis was present in 6 percent of US adult hospitalizations – JAMA Oct 2017
- 2.7 fewer days in hospital after surgery if had taken Omega-3 (19 RCT) – meta-analysis – June 2017
- Sepsis: 4 fewer days in ICU if add Omega-3 – meta-analysis of 12 RCT – June 2017
- Pro-inflammatory cytokines cause the 74 percent drop in vitamin D after knee arthroplasty – Feb 2014
- Critically ill patients with low vitamin D were 13X more likely to have a lot of mitrocondrial DNA in blood – Sept 2014
- More sepsis deaths when active vitamin D (Calcitrol) was low – May 2013
- Vitamin D decrease during inflammation is probably due to interferons - Oct 2012
- Vitamin D reduces sepsis
- Inflammation or surgery or heart attack decreases measured vitamin D levels – Mar 2011
Purpose Results of a meta-analysis of data from clinical studies comparing patient outcomes and hospital length of stay (LOS) in surgical patients receiving fish oil (FO)–containing i.v. fat emulsions (IVFEs) versus non–FO-containing IVFEs are presented.
Methods Computerized searches of the MEDLINE, Embase, and Coch rane CENTRAL databases were performed in August 2014 to identify English-language articles on randomized controlled trials (RCTs) comparing FO-containing and non–FO-containing IVFEs in adult surgical patients receiving parenteral nutrition. Selected articles were analyzed for methodological and publication bias and study heterogeneity (I2 statistic).
Results Data from 19 RCTs (total n = 1,167) were included in the meta-analysis. Compared with use of non–FO-containing IVFEs (products based in soybean oil [SO], medium-chain triglycerides, or olive oil), use of FO-containing IVFEs was associated with reduced infectious morbidity (odds ratio [OR], 0.44; 95% confidence interval CI, 0.30–0.65; p < 0.0001; I2 = 0%); the effect size was greatest for FO-containing versus SO-based IVFEs. Relative to use of SO-based IVFEs, use of FO-containing IVFEs was associated with a significant reduction in hospital LOS (weighted mean difference, −2.70 days; 95% CI, −3.60 to −1.79 days; p < 0.00001; I2 = 0%).
Conclusion The results of the meta-analysis indicated that FO-containing IVFEs could improve infectious morbidity and LOS. The overall effect of reducing infectious morbidity and LOS was found to be the greatest in comparison with the SO-based IVFEs.