Oral Vitamin D had a bigger response that injection in obese women - Jan 2024

---

Oral Vitamin D versus Injectable Vitamin D inTreating Obese Women with Vitamin D Deficiency

The Egyptian Journal of Hospital Medicine (January 2024) Vol. 94, Page 311-314
1* Shereen Mohammed Bahgat Awad, 2 Hosnia Mohammed Ragab, 3 Tarek ElHewala,
1 Nada Abbas Hassan, 1 Eman Mohamed Abd El-Sattar
1 Family Medicine Department, 2 Public Health and Community Medicine Department,
3 Orthopedic Surgery Department, Faculty of Medicine, Zagazig University, Egypt
Corresponding author: Shereen Mohammed Bahgat Awad, Email: drshereenbahgat at yahoo.com

20% of Obese women with injections still were < 20ng level

Background: Vitamin D deficiency is a widespread problem especially in females. The presence of different vitamin D preparations (oral, parenteral) with no definite evidence about the most appropriate method for vitamin D deficiency treatment aroused the need for more studies about the most effective route. Aim: To evaluate the oral vitamin D preparation compared to intramuscular (IM) vitamin D preparation in correcting vitamin D deficiency in affected women.

Subjects and methods: This is an interventional research performed on obese female patients diagnosed with vitamin D deficiency in the 2019-2022 timeframe for outpatient clinics at Zagazig University Hospitals. Eighty females were included in the study. They were allocated randomly into 2 equal groups (40 females per group); oral group and injection groups, based on their preference. Pre and post intervention assessment was done by assessing the level of serum vitamin D.

Results: There was statistically insignificant difference among studied groups concerning vitamin D level before therapy, while there was significant difference between them after therapy, where oral group had significantly higher level. Within each group, there was significant increase in vitamin D level after therapy. There was statistically significant positive correlation between percent of increase in vitamin D and both age and body mass index (BMI) of patients in the oral group, but no significant correlation was detected in injectable group between age and percent of change.

Conclusion: Treatment for vitamin D insufficiency works well when administered intramuscularly and orally but oral group showed more improvement.

---

I do not recall seeing this before

Is it due to obesity?
Or due to when the Vitamin D test was given relative to dosing time

---

VitaminDwiki – Injection contains

62 items in Vitamin D Injection category

• Vitamin D injections last longer (3 month vs 2 month) than loading doses
• Getting Vitamin D into your body shows the many ways of getting Vitamin D

• Injections are currently made by medical professionals into muscle
• Home injection of Vitamin D appears to be possible in the future
• Injections are useful for people who might forget to take their periodic supplement (children, elderly, etc) and those who cannot swallow or have poor digestion
• While Vitamin D2 is historically the common form, Vitamin D3 is far better
• Should check (if there is time) for possible allergic reaction to Vitamin D or lack of Magnesium for both for loading dose and injection
• Note 600,000 IU Vitamin D loading dose via capsules is 1/20th the cost($2.40) of an injection, and does not require a prescription
• 100,000 IU single dose of vitamin D - 2010 has the following
  
• Vitamin D injection lasts longer and has bigger response than weekly oral – Jan 2017 has the following
  
• Non-oral Vitamin D should be a better form for MS, food allergy, PTSD, etc. – many studies might include injection