Impact of Month of Birth on the Risk of Development of Autoimmune Addison's Disease.
J Clin Endocrinol Metab. 2016 Nov;101(11):4214-4218
Pazderska A1, Fichna M1, Mitchell AL1, Napier CM1, Gan E1, Ruchała M1, Santibanez-Koref M1, Pearce SH1.
1Institute of Genetic Medicine (A.P., A.L.M., C.M.N., E.G., M..S-K., S.H.P.), Newcastle University, Newcastle upon Tyne, NE1 3BZ United Kingdom; Institute of Human Genetics (M.F.), Polish Academy of Sciences, 60-479, Poznan, Poland; and Department of Endocrinology, Metabolism and Internal Medicine (M.F., M.R.), Poznan University of Medical Sciences, 60-355 Poznan, Poland.
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CONTEXT:
The pathogenesis of autoimmune Addison's disease (AAD) is thought to be due to interplay of genetic, immune, and environmental factors. A month-of-birth effect, with increased risk for those born in autumn/winter months, has been described in autoimmune conditions such as type 1 diabetes and autoimmune thyroid disease.
OBJECTIVE:
Month-of-birth effect was investigated in 2 independent cohorts of AAD subjects.
DESIGN, SETTING, AND PATIENTS:
The monthly distribution of birth in AAD patients was compared with that of the general population using the cosinor test. A total of 415 AAD subjects from the United Kingdom cohort were compared with 8 180 180 United Kingdom births, and 231 AAD subjects from the Polish cohort were compared with 2 421 384 Polish births.
MAIN OUTCOME MEASURES:
Association between month of birth and the susceptibility to AAD.
RESULTS:
In the entire cohort of AAD subjects, month-of-birth distribution analysis showed significant periodicity with peak of births in December and trough in May (P = .028). Analysis of the odds ratio distribution based on month of birth in 2 cohorts of patients with AAD versus the general population revealed a December peak and May trough, and January peak and July trough, in the United Kingdom and Polish cohorts, respectively.
CONCLUSION:
For the first time, we demonstrate that month of birth exerts an effect on the risk of developing AAD, with excess risk in individuals born in winter months and a protective effect when born in the summer. Exposure to seasonal viral infections in the perinatal period, coupled with vitamin D deficiency, could lead to dysregulation of innate immunity affecting the risk of developing AAD.
VitaminDWiki – Season of Birth category contains:
Season of birth is a good proxy for Vitamin D (for people far from the Equator)
Statistisically significant, but rarely greater than 20% change
Some health problems need Vitamin D in 2 or 3 trimesters, so are not associated with season
Perhaps some people in born in poor season will need more vitamin D all of their lives
Some Season of Birth studies
- Season of birth associated with many health problem (UK Biobank) – Nov 2020
- Preterm birth varies with season: 25 percent more likely if conception in autumn – Feb 2022
- Little sun in first trimester, 2.9 X more likely to have learning disabilities – June 2019
- UV at time of conception associated with Vitamin D Receptor activation 65 years later – Sept 2017
- Autoimmune Addison's Disease – increased risk if born in Dec or Jan – Nov 2016
- Schizophrenia increased 40 percent for Spring births after Danes stopped vitamin D fortification – April 2014
- Season of birth associated with Pneumonia (10 %) and Multiple Sclerosis (30 %) – May 2013
- Majority of Season of Birth health problems should vanish if take Vitamin D
100K monthly, or 50K bi-weekly, or 4K daily
See also VitaminDWiki
- Adrenal, Long-COVID and Vitamin D - several studies
- Autoimmune category listing has
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