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Overview Loading of vitamin D


If a person is, or is suspected to be, very vitamin D deficient a loading dose is typically given

  • Loading = repletion = quick replacement (previously known as Stoss)
  • Loading doses range in size from 100,000 IU to 1,000,000 IU of Vitamin D3
  • The size of the loading dose is a function of body weight - see below
    Unfortunately some doctors persist in using Vitamin D2 instead of D3, which has been shown to have many problems
  • Loading may be done as quickly as a single day, to as slowly as 3 months.
    It appears that spreading the loading dose over 4-20 days is a good compromise - not too fast, not too slow.
  • Loading is typically oral, but sometimes by injection (I.M,)
  • The loading dose persists in the body for about 3 months
    The loading dose should be followed up with continuing maintenance - typically 4,000 to 10,000 IU daily average
    Unfortunately many doctors fail to follow-up with the maintenance dosing.
  • As about 1 in 300 people have some form of mild allergic reaction to vitamin D supplements,
    it appears prudent to test with a small amount of the exact form of vitamin D before giving a loading dose
    Causes for a mild allergic reaction appear to be: (in order of occurance)
    1) lack of magnesium - which can be easily added
    2) allergy to capsule contents - oil (powder does not appear to cause any reaction)
    3) allergy to the tiny amount of D3 itself (allergy to wool) ( alternate: D3 made from plants )


Cholecalciferol loading dose guideline for vitamin D-deficient adults.

Eur J Endocrinol. 2010 Apr;162(4):805-11. Epub 2010 Feb 5.

CONCLUSION: The cholecalciferol loading dose required to reach the serum 25-OHD(3) target level of 75 nmol/l can be calculated as follows:
dose (IU)=40x(75 - serum 25-OHD(3))xbody weight.
CLICK HERE for PDF of the study and equation
Equation converted into units of ng and pounds
    Dose to get 30 ng (in ng and pounds) = 35 x (30 - serum 25-OHD(3)) x body weight.
Typically spread over over 8 weeks
A very commonly prescribed loading dose in the US is 50,000 IU per week for 8 weeks, for a total of 400,000 IU
Example uses of the equation to achieve 30 ng (on average)

Dose starting
level
weight
140,000 IU 10 ng 200 lb
70,000 IU 20 ng 200 lb
105,000 IU 10 ng 150 lb


Dose to get 50 ng (in ng and pounds) = 35 x (50 - serum 25-OHD(3)) x body weight.
Example uses of the equation to achieve 50 ng (on average)

Dose starting
level
weight
280,000 IU 10 ng 200 lb
210,000 IU 20 ng 200 lb

There is a HUGE variation in response between individuals for the average (equation)
Image


Fastest response time for a loading dose


See also at VitaminDWiki

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See also web


Page last modified on 08 October, 2014


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Health Problems and D

  # of studies as of 9/30/14