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Prefer more than 30 ng of Vitamin D and 700 mg Calcium to treat Osteoporosis – Mar 2011

Optimal Use of Vitamin D When Treating Osteoporosis

Curr Osteoporos Rep. 2011 March; 9(1): 36–42.
Published online 2010 November 27. doi: 10.1007/s11914-010-0041-0.
Joop P. W. van den Bergh,1,2 jvdbergh at hetnet.nl., Sandrine P. G. Bours,3 Tineke A. C. M. van Geel,4 and Piet P. Geusens5,6
1Department of Internal Medicine, VieCuri Medical Centre Noord-Limburg, P.O. Box 1926, 5900 BX Venlo, The Netherlands
2Faculty of Health Medicine and Life Science, Department of Internal Medicine, Maastricht University Medical Centre/Nutrim, P.O. Box 616, 6200 MD Maastricht, The Netherlands
3Department of Internal Medicine, Subdivision Endocrinology, Maastricht University Medical Centre, Maastricht, P.O. Box 616, 6200 MD Maastricht, The Netherlands
4Faculty of Health Medicine and Life Science, Department of General Practice, Maastricht University Medical Centre/Caphri, P.O. Box 616, 6200 MD Maastricht, The Netherlands
5Faculty of Health Medicine and Life Science, Department of Internal Medicine, Maastricht University/Caphri, P.O. Box 616, 6200 MD Maastricht, The Netherlands
6Biomedical Research Center, University Hasselt, Hasselt, Belgium

Inadequate serum 25-hydroxyvitamin D (25OHD) concentrations are associated with muscle weakness, decreased physical performance, and increased propensity in falls and fractures. This paper discusses several aspects with regard to vitamin D status and supplementation when treating patients with osteoporosis in relation to risks and prevention of falls and fractures. Based on evidence from literature, adequate supplementation with at least 700 IU of vitamin D, preferably cholecalciferol, is required for improving physical function and prevention of falls and fractures. Additional calcium supplementation may be considered when dietary calcium intake is below 700 mg/day. For optimal bone mineral density response in patients treated with antiresorptive or anabolic therapy, adequate vitamin D and calcium supplementation is also necessary. Monitoring of 25(OH)D levels during follow-up and adjustment of vitamin D supplementation should be considered to reach and maintain adequate serum 25(OH)D levels of at least 50 nmol/L, preferably greater than 75 nmol/L in all patients. PMCID: PMC3026680

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