Need 9600 IU Vitamin D to get most people to 40 ng – with graph Feb 2011
Vitamin D Supplement Doses and Serum 25-Hydroxyvitamin D in the Range Associated with Cancer Prevention
CEDRIC F. GARLAND 1, CHRISTINE B. FRENCH 2, LEO L. BAGGERLY 2 and ROBERT P. HEANEY 3
1 University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, U.S.A.;
2 GrassrootsHealth, P.O. Box 234208, Encinitas, CA 92023, U.S.A.;
3 Creighton University, 2500 California Plaza, Omaha, NE 68178, U.S.A.
Background: Studies indicate that intake of vitamin D in the range from 1,100 to 4,000 IU/d and a serum 25- hydroxyvitamin D concentration [25(OH)D] from 60-80 ng/ml may be needed to reduce cancer risk. Few community-based studies allow estimation of the dose-response relationship between oral intake of vitamin D and corresponding serum 25(OH)D in the range above 1,000 IU/d.
Materials and Methods: A descriptive study of serum 25(OH)D concentration and self-reported vitamin D intake in a community-based cohort (n=3,667, mean age 51.3 ±13.4 y).
Results: Serum 25(OH)D rose as a function of self-reported vitamin D supplement ingestion in a curvilinear fashion, with no intakes of 10,000 IU/d or lower producing 25(OH)D values above the lower-bound of the zone of potential toxicity (200 ng/ml). Unsupplemented all-source input was estimated at 3,300 IU/d.
The supplemental dose ensuring that 97.5% of this population achieved a serum 25(OH)D of at least 40 ng/ml was 9,600 IU/d.
Need 14,100 IU/d to get 97.5% of the population above 50 ng/ml
Conclusion: Universal intake of up to 40,000 IU vitamin D per day is unlikely to result in vitamin D toxicity
Dose-response graph from the paper
Note: no apparent data below 33 ng and calculation does NOT account for skin color, BMI, latitude, age, co-factors, state of health, etc.
CLICK HERE for PDF
Other interesting graphs in the paper include
Half of seniors did not respond to 1600 IU of vitamin D daily for a year
RED square = reduction in serum level
from slide presentation: http://www.vitamindwiki.com/tiki-index.php?page_id=2269
See also VitaminDWiki
- Is 50 ng of vitamin D too high, just right, or not enough
- 85% achieved 20 nanograms with daily average of 3300 IU of vitamin D
- All items in category How Much Vitamin D 258 items
- More response to 1100 IU vitamin D in cold season or less BMI – May 2012
- 800 IU vitamin D resulted in 20 ng, 3200 IU resulted in 45 ng – RCT March 2012
- How to 2X the response to vitamin D supplements
- How to increase the vitamin D you get from time in the sun
- Dose response equation square root of IU
- Charts of Disease incidence vs ng
- Recommendations for vitamin D since 2009 both IU and ng/ml
- Every 400 IU increase of vitamin D3 increases serum level about 8 ng– Systematic Review Aug 2012
- Overview Loading of vitamin D people who are very vitamin D deficient should consider loading dose to get vitamin D levels as soon as possible
- Vitamin D levels vs weight – RCT Dec 2012
- Higher BMI decreased response to 700 IU vitamin D – RCT 2008
- Grassroots Health participants Vitamin D vs age, intake, and resulting level – Sept 2013
- Overview How Much vitamin D
- Endocrine Society Guideline should be raised to 2 ng per 100 IU of vitamin D – March 2013
- All items in category Predict Vitamin D 28 items
- Review of bioavailability of vitamin D - oil aprox 2 ng per 100 IU Sept 2010
- 50,000 IU vitamin D weekly increased levels by 52 ng normally, but only 28 ng if obese – Oct 2013
- Huge gap between vitamin D advice and actual prescriptions – April 2012
- Dose/response graph from GrassRoots
- Notice that response to 5000 IU varied from 30 ng to 140 ng
- Another dose response graph
Approx 5,000 IU got the average to 45 ng, while one only got to 24 ng, but another achieved 65 ng
- Response to Vitamin D: summary chart of 8 studies – March 2013 shows 5,000 IU dose would get avg of 60 ng
Would higher dose to get a majority (say 97%) above 40 ng
Short url = http://is.gd/doseresponse