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Overview Cardiovascular and vitamin D

Did you know?

Many studies show that cardiovascular problems are treated & prevented by Vitamin D
  As with many other health problems:
  More Vitamin D is needed to treat than to prevent
  Omega-3, Magnesium, and Vitamin K2 also probably also help
      (More Cardiovascular info below this box)
Learn how Vitamin D is essential for good health
  Watch a 5 minute video "Does Less Sun Mean more Disease?"
  Browse for other Health Problems and D in left column
  Click About Vitamin D in menu above

See also VitaminDWiki: Cardiovascular - general

derived from Grassroots 2013



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Pages listed in BOTH the categories Vitamin K and Cardiovascular __

See also in VitaminDWiki Cardiovascular and MORTALITY

See also in VitaminDWiki HYPERTENSION and BLOOD PRESSURE

See also in VitaminDWiki STROKES

See also in VitaminDWiki Metabolic Syndrome

See also web

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MAYO Clinic April 2012: Pathways from vitamin D Deficiency to CVD

see wikipage http://www.vitamindwiki.com/tiki-index.php?page_id=1422

The effect of vitamin D status on risk factors for cardiovascular disease Nature 2013

$4 to rent the PDF - but the following chart from the study is on Google images
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Random controlled trial found NO BENEFIT with 50,000 IU weekly - Feb 2013 - strange

A randomized controlled trial of high dose vitamin D3 in patients with heart failure.
JACC Heart Fail. 2013 Feb;1(1):84-90. doi: 10.1016/j.jchf.2012.11.003.
Boxer RS1, Kenny AM2, Schmotzer BJ3, Vest M4, Fiutem JJ5, Piña IL6.

OBJECTIVE: To investigate the effect of Vitamin D3 on physical performance in patients with HF.

BACKGROUND: HF is associated with functional decline and frailty. Vitamin D deficiency is associated with loss of muscle strength and poor outcomes in patients with HF.

METHODS: Sixty-four patients participated in a 6-month parallel design double blind RCT to test the hypothesis that oral vitamin D3 would improve physical performance. Vitamin D3 50,000 IU or placebo was given weekly; all received daily calcium. Patients were included regardless of EF and 25OHD ≤ 37.5 ng/ml. The primary outcome was peak VO2, and secondary outcomes were the 6MW, TGUG and knee isokinetic muscle strength. Between group comparisons were made using ANCOVA models that adjust for baseline measures.

RESULTS: Patients were age 65.9 ± 10.4 years old, 48% women, 64% African American, EF 37.6±13.9, 36% NYHA III, the remainder NYHA II.
At baseline the vitamin D group 25OHD was 19.1 ± 9.3 ng/ml and increased to 61.7 ± 20.3 ng/ml; in the placebo group baseline 25OHD was 17.8 ± 9.0 ng/ml and decreased to 17.4 ± 9.8 ng/ml at 6 months (between groups p<0.001).
There was no significant change from baseline to 6 months in peak VO2, 6MW, TGUG or isokinetic muscle strength.

CONCLUSIONS: Vitamin D3 did not improve physical performance for patients with HF despite a robust increase in serum 25OHD.
Vitamin D repletion in patients with HF should conform to standard adult guidelines for vitamin D supplementation.

PMID: 24614995
 Download the PDF from VitaminDWiki.

Strange - seems like the study did things correctly.Good amount of vitamin D, trial lasted long enough, vitamin D levels were raised high enough. Yet no benefit.


INTERVENTION Clinical Trials for (heart OR cardiovascular) and "vitamin D" 294 as of Feb 2015

  • Intervention = give vitamin D and see what happens usually testing vitamin D vs placebo
  • The majority of these intervention trials are for TREATMENT, rather than prevention
  • Vitamin D and cardiovascular disease preventiom May 2016
    Large Ongoing Random Controlled CVD trials
    No apparent attempt to trial those with low levels of vitamin D,
    No Magnesium added,
    No Omega-3 added,
    Not much vitamin D used - especially since statins used with CVD reduce the vitamin D
    No Vitamin K2 to stop Calcium increased by Vitamin D from coating the arteries

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68 proofs that Vitamin D works (as of March 2016)

Proof that Vitamin D Works has the following

Health Problem Treat
Prevent
Reduction
   click for details
RCT = Random Controlled Trial
   * = link to additional RCT
CT = Clinical Trial
Vitamin
DWiki
  #
HypertensionT 149 to 142 mm Hg RCT*  *?, 2400 IU.  100,000 IU* 1
Cardiovascular after attack T 32 % fewer deaths CT 1000 IU2
Diabetes T2T 62 % RCT* *, CRP reduction, 4000 IU 4
Congestive Heart Failure T 90 % RCT, 1000 IU infants (also: Adults, not RCT) 27
After Heart Attack T __+6% ejection fraction RCT, 800,000 IU one time34

See also: Fish Oil / Omega-3


Short url = http://bit.ly/Zczfrw



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List of attached files
ID Name desc uploaded Size Downloads Actions
6793 jpg CVD RCT.jpg 15 June, 2016 by admin 64.42 Kb 204 View Download  
4999 pdf Heart Failure.pdf PDF 2013 01 Feb., 2015 by admin 324.72 Kb 556 View Download  
4822 jpg Cardio Nature 2013.jpg 04 Jan., 2015 by admin 83.96 Kb 1858 View Download  
3642 pdf Cardiovascular - Feb 2014.pdf PDF 2014 22 Feb., 2014 by admin 953.07 Kb 1131 View Download  
2869 pdf Cardiac 2012.pdf PDF 04 Aug., 2013 by admin 738.94 Kb 2553 View Download  
2366 pdf Afib Mayo.pdf PDF 14 Apr., 2013 by admin 397.95 Kb 1707 View Download  
1322 jpg CVD 2X.jpg 12 May, 2012 by admin 46.99 Kb 3489 View Download  
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