Proof that Vitamin D Works

50 health problems prevented or treated by Vitamin D - as of Dec 2014

Hypertension, Cardiovascular, Back Pain, Diabetes, Influenza, Falls, Hip Fractures, Breast Cancer, Multiple Sclerosis, Raynaud's pain, Menstrual Pain, C-section and pregnancy risks, Low Birth Weight, Chronic Kidney Disease, Cystic Fibrosis, Rheumatoid Arthritis, TB, Rickets, Respiratory Tract Infection, Lupus, Sickle Cell pain, leg ulcers, traumatic brain injury. Parkinson's Disease, Multiple Sclerosis, Congestive Heart Failure (Infants), Middle Ear Infection (Infants), Gingivitis, stronger senior muscles, antibiotic use in seniors, short Infants, Gestational Diabetes, heart pump better after attack, Prostate Cancer, Asthma, Depression, Vitamin D in Breastmilk, Fibromyalgia, Chronic Hives, Cholesterol, Weight loss, COPD, Asthma, Quality of Life, Survive ICU, Restless Leg Syndrome, Hepatitis-C

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  * The only RCT available when the Institute of Medicine decided how much vitamin D was needed

PDF is attached at the bottom of this June 2014, 1 page, legal size, English
Most proofs are RCT (Random Controlled Trials), where not even the doctor knows who gets the extra vitamin D
Two are meta-analysis of multiple RCTs
or Researchers felt that it was unethical to not give vitamin D to everyone (for example: #43)
or #9 Gave vitamin D to ALL infants in the entire country (Rickets)

(Note: 3/4 of the Proofs were in 2012 and 2013 - as of Dec 4 2013)

Vitamin D intervention – 1204 clinical trials – May 2014

How often might 50000 IU vitamin D be taken - results of clinical trials re-arranges the above data (May 2014) by dose size

Observation by Henry Lahore of VitaminDWiki Dec 2013

As far as I am aware:    Every single clinical trial which used enough Vitamin D for long enough got great results.

Many Clinical Trials do not find a benefit because of one or more of the following faiures:

  1. Fails to use a large enough dose of vitamin D (often < 1,100 IU)
    Even larger dose needed if: 1) obese, 2) poor gut, 3) sick (many diseases consume lots of vitamin D)
  2. Fails to have given vitamin D for a long enough time (a few RCT lasted less than 5 weeks)
  3. Fails to have given Vitamin D frequently enough. At least every 2 months for D3) - and at least weekly for D2
    Note: Infrequent dosing also causes unbalancing of the body's chemistry
  4. Fails to provide a loading dose, or had too short a duration to restore the vitamin D levels
  5. Fails to use D3 form, instead uses the less effective D2 form
  6. Fails to have a health range of Calcium or other important cofactors (especially for bone-related trials
    Also, differences in Magnesium can result in 30% change in response to vitamin D
    Magnesium is dependant on water, food, supplements
  7. Fails to notice the pre-existing vitamin D levels - only those who are low will likely show a benefit
  8. Fails to notice how/when the vitamin D was taken (which can change the response by as much as 2X)
  9. Fails to reports on compliance (in one case 40% of the participants did not take the supplements consistantly)

Many Meta-Analysis also do not find a benefit because one or more of the above failures
In addition, many meta-analysis average together ALL of the trials
Imagine a story about a meta-analysis of aspirin (which has never been done)
   There would be scores of RCT for aspirin not working with 3 mg doses
   There would be many RCT of aspirin not working with 30 mg doses
   There would be a few studies of aspirin WORKING with 300+ mg doses
   There would be many studies of small amounts of Willow bark (Vitamin D2 instead of Vitamin D3)
   Then were would be a meta-analysis of aspirin and Willow Bark
   - That meta-analysis would conclude that aspirin and Willow bark do not work.

While about 200 RCTs will be published during 2014, I anticipate only adding 50 to the proofs table due to the reasons listed above
   Also, some trials will not get started due to lack of people willing to go for years with < 500 IU of vitamin D

See also VitaminDWiki: Random Controlled Trials with vitamin D intervention

More intervention trials for Vitamin D than for the TOTAL of Vitamins A + C + E + K combined

Vitamin D= 915, Others = 798 [ Vitamin A 188 + Vitamin C 269 + Vitamin E 236 + Vitamin K 105 ]   as of Sept 2012

See also VitaminDWiki


CLICK ON chart for more information and translation

See also web

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Health Problems and D

  # of studies as of 12/20/14