Proof that Vitamin D Works


70 health problems prevented or treated

Health Problem
Reduction by Vit D
   click for details
RCT = Random Controlled Trial
   * = link to additional RCT
CT = Clinical Trial
HypertensionT 149 to 142 mm Hg RCT*  *, 2400 IU.  100,000 IU*
Cardiovascular after attack T 32 % fewer deaths CT 1000 IU
Diabetes Type 1 P 85 % 12000 kids, 2000 IU
Diabetes Type 2T 62 % RCT* *, CRP reduction, 4000 IU
Back Pain T 95 % 5000/10000 IU
Influenza P 90 % RCT *, 2000 IU
Falls P 50%RCT, 100,000 IU monthly
RCT with Meals on Wheels 2016
Hip Fractures P 30 % RCT * 800 IU
Rickets P 98 % Turkey, 400 IU
Raynaud's Syndrome T 40 % RCT, visual scale, 20000 IU Avg
Menstrual pain P 76 % RCT, 7000 IU Avg, PMS reduced by half
Pregnancy risks P 50 % RCT, 4000 IU
C-section, unplanned P 50 % RCT, 4000 IU, small study
Low birth weight P 60 % RCT * 1000 IU of D2
TBP 60 % RCT, 800 IU
Breast Cancer P 60 % RCT, 1100 IU (2007)
Rheumatoid Arthritis pain T 40 % RCT, 500 IU, added to prescription
Cystic Fibrosis T 75 % RCT, pilot 4X fewer deaths 250,000 IU
Chronic Kidney T 90 to 70 PTH RCT, 3500 IU,
Respiratory Tract Infection P 63 % RCT, 4000 IU 1 year 2nd RCT: 2000/800 IU
3rd RCT 20,000 IU weekly
Lupus T zero flares Loading then 100,000 IU monthly, RCT too
Sickle Cell T Less pain RCT, up to 100,000 IU/week
Leg ulcer healing T 4X faster RCT, 50,0000 IU/week, small study
Traumatic Brain Injury T 2X RCT, 20,0000 IU/day with progesterone
Parkinson's DiseaseT StabilizedRCT, 1200 IU/day
Multiple SclerosisP 68%RCT, 7100 IU prevent pre-MS ==> MS
Congestive Heart Failure T 90 % RCT, 1000 IU infants (also: Adults, not RCT)
Middle Ear Infection P 30 % RCT, 1000 IU infants
GingivitisT 88 %RCT, 2000 IU
Muscle in seniors T 17 % more muscle RCT, 4000 IU
Antibiotic use when >70y T 47 % RCT, 60,000 IU monthly
Infants tallerBenefit1 cm tall RCT, 50,000 IU weekly, 8 weeks
Gestational Diabetes T Treated RCT, 2 doses of 50,000 IU
After Heart Attack T +6% ejection fraction RCT, 800,000 IU one time
Prostate Cancer T Fewer +cores RCT, 4000 IU (2012)
Asthma T Reduced symptoms RCT, 60K IU/month;   RCT 50K IU/week
Meta-analysis of Asthma intervention
Depression T Reduced RCT, 300,000 IU injection RCT helped Prozac
Low vitamin D while breastfed P All infants > 20 mg RCT, 5,000 IU
Fibromyalgia T Reduced RCT, 30-48 ng   RCT 50K IU/week
Hives, Chronic T Reduced 40% RCT, 4000 IU added
CholesterolT Reduced 4 mg RCT, 400 IU + Ca
Weight Loss T lost 5 more lbs RCT, 2000 IU +diet +exercise
Multiple Sclerosis T 95% were CURED 20,000 to 140,000 IU/day
Gestational DiabetesP 40% RCT * , 5,000 IU
Chronic Obstructive
Pulmonary Disease
T 17X improvement CT, 50,000 IU weekly
RCT 100,000 IU monthly
Asthma T 1/2 Asthma attacks RCT >42 mg of vitamin D
Quality of Life (QoL) T Nursing Home QoL CT, 4,000 IU in daily bread
Death of Critically Ill Patients T 20% increase in survivability RCT 540 K IU loading than 90K monthly
Restless Leg Syndrome T Score 26 ==> 10 CT, Vitamin D dose size not state in abstract
Hepatitis-C T Enhanced conventional drugs RCT 2.000 IU
Chron's disease? T improved when > 30 ngRCT 2,000 IU
Pre-term birth P 2.5X decrease, also:
fewer c-section & better Apgar
RCT 2,000 IU India
Lupus T Pain reduced RCT 4,000 IU
Cluster headaches T CH eliminated in 60% 10,000 IU, Mg, Omega-3, etc
Autism T 80% improved CT 300 IU/kg/day for 3 months
PreDiabetes T ~20% reduced RCT 60,000 IU/month
Weight loss:
Overweight and Obese
T 12 lbs in 6 months RCT 100,000 IU/month
Sarcopenia = muscle loss T 27% increase RCT 1,000 IU
Growing Pains T 60% decrease ~100,000 IU/month -NOT RCT, given to all
2nd study, similar results
Osteoarthritis pain T 60% decrease 50,000 IU/weekly - NOT RCT, given to all
Amyotrophic Lateral Sclerosis T helped 2,000 IU - NOT RCT, given to all
Vertigo T 3X reduction if raised > 10ng 600,000 IU load, then maint. - NOT RCT, given to all
Warts T 80% eliminated injection NOT RCT, given to all
Metabolic Syndrome P reduced 44% when VitD
increased by 30 ng
NOT RCT -given to all
Hay fever P 1,000 IU for 30 days RCT
Preeclampsia P 50,000 IU every 2 weeksRCT
Blood cell cancer T Multiple MyelomaNOT RCT -given to all
Irritable Bowel Syndrome? T 3,000 IU sprayRCT
Urinary Tract Infection P 50% reduction RCT 20,000 IU weekly
Mite Allergy P 5X reductionRCT April 2016: 2,000 IU preg, 800 IU child

You can click underlined items to get details    Short url for this table =    is.gd/proofvitd

Note: Many recent proofs are NOT RCT (where half of the people get no/little vitamin D)
Perhaps researchers feel it is morally wrong to not give vitamin D to all participants.
Or perhaps researches are unable to find enough people who do not want a 50% change of getting zero or little vitamin D
 Download the 47 proof PDF of June 2014 - Legal Size English

Most proofs are RCT (Randomized Controlled Trials), where not even the doctor knows who gets the extra vitamin D

  • 2 are meta-analysis of multiple RCTs
  • In #9 vitamin D given to ALL infants in the entire country (Rickets)
  • In several studies researchers felt that it was unethical to not give vitamin D to everyone (e.g. #43)
  • In some studies the dose size varied with the needs of the person (overweight, etc)
  • In some studies the COFACTORS were adjusted with the needs of the patient
  • As of Jan 2015 41 health problems have been proven to be prevented/treated by Vitamin D in 51 different RCT
  • By the way - the health problems which were CURED by vitamin D have not been RCT
    and we expect never will be, proven by Random Controlled Trials.
    Curing requires the dose size and cofactors to be adjusted to the needs of each patient.

(Note: 3/4 of the Proofs were in 2012 and 2013 - as of Dec 4 2013)

How often might 50000 IU vitamin D be taken - results of clinical trials
sorts the table (of May 2014) by dose size

Many Clinical Trials have not found a benefit because of one or more of the following failures:

  1. Fails to use a large enough dose of vitamin D (often < 1,100 IU)
    The Even larger dose needed if: 1) obese, 2) poor gut, 3) sick (many diseases consume lots of vitamin D)
  2. Fails to have given vitamin D for a long enough time (a few RCT lasted less than 5 weeks)
  3. Fails to have given Vitamin D frequently enough. At least every 2 months for D3) - and at least weekly for D2
    Note: Infrequent dosing also causes unbalancing of the body's chemistry
  4. Fails to provide a loading dose, or had too short a duration to restore the vitamin D levels
  5. Fails to use D3 form, instead uses the less effective D2 form
  6. Fails to have a healthy range of Calcium or other important cofactors (especially for bone-related trials
    Also, differences in Magnesium can result in 30% change in response to vitamin D
    Magnesium is dependant on water, food, supplements
  7. Fails to notice the pre-existing vitamin D levels - only those who are low will likely show a benefit
  8. Fails to notice how/when the vitamin D was taken (which can change the response by as much as 2X)
  9. Fails to report on compliance (in one case 40% of the participants did not take the supplements consistently)

Many Meta-Analysis also do not find a benefit because one or more of the above failures
In addition, many meta-analysis average together ALL of the trials
Imagine a story about a meta-analysis of aspirin (which has never been done)
   There would be scores of RCT for aspirin not working with 3 mg doses
   There would be a many RCT of aspirin not working with 30 mg doses
   There would be a few studies of aspirin WORKING with 300+ mg doses
   There would be many studies of small amounts of Willow bark (Vitamin D2 instead of Vitamin D3)
   Then there would be a meta-analysis of aspirin and Willow Bark
   - That meta-analysis would conclude that aspirin and Willow bark do not work.

While about 200 RCTs will be published during 2014, I anticipate only adding 50 to the proofs table due to the reasons listed above
   Also, some trials will not get started due to lack of people willing to go for years with < 500 IU of vitamin D

See also VitaminDWiki: Random Controlled Trials with vitamin D intervention

More intervention trials for Vitamin D than for the TOTAL of Vitamins A + C + E + K combined

Vitamin D= 915, Others = 798 [ Vitamin A 188 + Vitamin C 269 + Vitamin E 236 + Vitamin K 105 ]   as of Sept 2012

See also VitaminDWiki


CLICK ON chart for more information and translation

List of diseases in the table at the top of this page

Hypertension, Cardiovascular, Back pain, Diabetes, Influenza, Falls, Hip Fractures, Breast Cancer, Multiple Sclerosis, Raynaud's pain, Menstrual Pain, C-section and pregnancy risks, Low Birth Weight, Chronic Kidney Disease, Cystic Fibrosis, Rheumatoid Arthritis, TB, Rickets, Respiratory Tract Infection, Lupus, Sickle Cell, leg ulcers, traumatic brain injury. Parkinson's Disease, Multiple Sclerosis, Congestive Heart Failure (Infants), Middle Ear Infection (Infants), Gingivitis, stronger senior muscles, antibiotic use in seniors, short Infants, Gestational Diabetes, heart pump better after the attack, Prostate Cancer, Asthma, Depression, Vitamin D in Breast Milk, Fibromyalgia, Chronic Hives, Cholesterol, Weight loss, COPD, Asthma, Quality of Life, Survive ICU, Restless Leg Syndrome, Hepatitis-C, Chron's disease, Pre-term birth, Lupus, Cluster headaches, Autism. PreDiabetes, Weight loss; Sarcopenia = muscle loss; Growing Pains, Osteoarthritis, ALS ,Vertigo, Warts, Metabolic Syndrome, Hay fever, Preeclampsia, Blood cell cancer, Irritable Bowel Syndrome, Urinary Track Infection, Mite Allergy

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