Proof that Vitamin D Works


63 health problems prevented or treated


You can click underlined items to get details    Short url for this table =    is.gd/proofvitd

Note: The last 4 proofs are NOT RCT (where half of the people get no/little vitamin D)
It appears that researchers feel it is morally wrong to not give vitamin D to all participants
Would be nice if doctors would also feel it is morally wrong to fail to give vitamin D to their patients

 Download the 47 proof PDF of June 2014 - Legal Size English

Most proofs are RCT (Randomized Controlled Trials), where not even the doctor knows who gets the extra vitamin D

  • 2 are meta-analysis of multiple RCTs
  • In #9 vitamin D given to ALL infants in the entire country (Rickets)
  • In several studies researchers felt that it was unethical to not give vitamin D to everyone (e.g. #43)
  • In some studies the dose size varied with the needs of the person (overweight, etc)
  • In some studies the COFACTORS were adjusted with the needs of the patient
  • All but 2, 3, 5, 9, 43, 45, 47, 49 are Random Controlled Trials
  • As of Jan 2015 41 health problems have been proven to be prevented/treated by Vitamin D in 51 different RCT
  • By the way - the health problems which were CURED by vitamin D have not been,
    and we expect never will be, proven by Random Controlled Trials.
    Curing requires the dose size and cofactors to be adjusted to the needs of the patient.

(Note: 3/4 of the Proofs were in 2012 and 2013 - as of Dec 4 2013)

How often might 50000 IU vitamin D be taken - results of clinical trials
sorts the table (of May 2014) by dose size

Many Clinical Trials have not found a benefit because of one or more of the following failures:

  1. Fails to use a large enough dose of vitamin D (often < 1,100 IU)
    The Even larger dose needed if: 1) obese, 2) poor gut, 3) sick (many diseases consume lots of vitamin D)
  2. Fails to have given vitamin D for a long enough time (a few RCT lasted less than 5 weeks)
  3. Fails to have given Vitamin D frequently enough. At least every 2 months for D3) - and at least weekly for D2
    Note: Infrequent dosing also causes unbalancing of the body's chemistry
  4. Fails to provide a loading dose, or had too short a duration to restore the vitamin D levels
  5. Fails to use D3 form, instead uses the less effective D2 form
  6. Fails to have a healthy range of Calcium or other important cofactors (especially for bone-related trials
    Also, differences in Magnesium can result in 30% change in response to vitamin D
    Magnesium is dependant on water, food, supplements
  7. Fails to notice the pre-existing vitamin D levels - only those who are low will likely show a benefit
  8. Fails to notice how/when the vitamin D was taken (which can change the response by as much as 2X)
  9. Fails to report on compliance (in one case 40% of the participants did not take the supplements consistently)

Many Meta-Analysis also do not find a benefit because one or more of the above failures
In addition, many meta-analysis average together ALL of the trials
Imagine a story about a meta-analysis of aspirin (which has never been done)
   There would be scores of RCT for aspirin not working with 3 mg doses
   There would be a many RCT of aspirin not working with 30 mg doses
   There would be a few studies of aspirin WORKING with 300+ mg doses
   There would be many studies of small amounts of Willow bark (Vitamin D2 instead of Vitamin D3)
   Then there would be a meta-analysis of aspirin and Willow Bark
   - That meta-analysis would conclude that aspirin and Willow bark do not work.

While about 200 RCTs will be published during 2014, I anticipate only adding 50 to the proofs table due to the reasons listed above
   Also, some trials will not get started due to lack of people willing to go for years with < 500 IU of vitamin D

See also VitaminDWiki: Random Controlled Trials with vitamin D intervention

More intervention trials for Vitamin D than for the TOTAL of Vitamins A + C + E + K combined

Vitamin D= 915, Others = 798 [ Vitamin A 188 + Vitamin C 269 + Vitamin E 236 + Vitamin K 105 ]   as of Sept 2012

See also VitaminDWiki


CLICK ON chart for more information and translation

List of diseases in the table at the top of this page

Hypertension, Cardiovascular, Back pain, Diabetes, Influenza, Falls, Hip Fractures, Breast Cancer, Multiple Sclerosis, Raynaud's pain, Menstrual pain, C-section and pregnancy risks, Low Birth Weight, Chronic Kidney Disease, Cystic Fibrosis, Rheumatoid Arthritis, TB, Rickets, Respiratory Tract Infection, Lupus, Sickle Cell pain, leg ulcers, traumatic brain injury. Parkinson's Disease, Multiple Sclerosis, Congestive Heart Failure (Infants), Middle Ear Infection (Infants), Gingivitis, stronger senior muscles, antibiotic use in seniors, short Infants, Gestational Diabetes, heart pump better after the attack, Prostate Cancer, Asthma, Depression, Vitamin D in Breast Milk, Fibromyalgia (pain), Chronic Hives, Cholesterol, Weight loss, COPD, Asthma, Quality of Life, Survive ICU, Restless Leg Syndrome, Hepatitis-C, Chron's disease, Pre-term birth, Lupus, Cluster headaches (pain), Autism. PreDiabetes, Weight loss; Sarcopenia = muscle loss; Growing pains, Osteoarthritis pain, ALS ,Vertigo

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