Proof that Vitamin D Works


53 health problems prevented or treated by Vitamin D


You can click underlined items to get details    Short url for this table =    is.gd/proofvitd

PDF is attached at the bottom of this June 2014, 1 page, legal size, English
Most proofs are RCT (Random Controlled Trials), where not even the doctor knows who gets the extra vitamin D

  • 2 are meta-analysis of multiple RCTs
  • In #9 vitamin Dgiven to ALL infants in the entire country (Rickets)
  • In several studies researchers felt that it was unethical to not give vitamin D to everyone (e.g. #43)
  • In some studies the dose size varied with the needs of the person (overweight, etc)
  • In some studies the COFACTORS were adjusted with the needs of the patient
  • All but 2, 3, 5, 9, 43, 45, 47, 49 are Random Controlled Trials
  • As of Jan 2015 41 health problems have been proven to be prevented/treated by Vitamin D in 51 different RCT
  • By the way - the health problems which were CURED by vitamin D have not been,
    and we expect never will be, proven by Random Controlled Trials.
    Curing requires the dose size and cofactors to be adjusted to the needs of the patient.

(Note: 3/4 of the Proofs were in 2012 and 2013 - as of Dec 4 2013)

Vitamin D intervention – 1204 clinical trials – May 2014

How often might 50000 IU vitamin D be taken - results of clinical trials
sorts the table (of May 2014) by dose size

Observation by Henry Lahore of VitaminDWiki Dec 2013

As far as I am aware:    Every single clinical trial, which used enough Vitamin D for long enough, got great results.

Many Clinical Trials do not find a benefit because of one or more of the following failures:

  1. Fails to use a large enough dose of vitamin D (often < 1,100 IU)
    The Even larger dose needed if: 1) obese, 2) poor gut, 3) sick (many diseases consume lots of vitamin D)
  2. Fails to have given vitamin D for a long enough time (a few RCT lasted less than 5 weeks)
  3. Fails to have given Vitamin D frequently enough. At least every 2 months for D3) - and at least weekly for D2
    Note: Infrequent dosing also causes unbalancing of the body's chemistry
  4. Fails to provide a loading dose, or had too short a duration to restore the vitamin D levels
  5. Fails to use D3 form, instead uses the less effective D2 form
  6. Fails to have a healthy range of Calcium or other important cofactors (especially for bone-related trials
    Also, differences in Magnesium can result in 30% change in response to vitamin D
    Magnesium is dependant on water, food, supplements
  7. Fails to notice the pre-existing vitamin D levels - only those who are low will likely show a benefit
  8. Fails to notice how/when the vitamin D was taken (which can change the response by as much as 2X)
  9. Fails to report on compliance (in one case 40% of the participants did not take the supplements consistently)

Many Meta-Analysis also do not find a benefit because one or more of the above failures
In addition, many meta-analysis average together ALL of the trials
Imagine a story about a meta-analysis of aspirin (which has never been done)
   There would be scores of RCT for aspirin not working with 3 mg doses
   There would be a many RCT of aspirin not working with 30 mg doses
   There would be a few studies of aspirin WORKING with 300+ mg doses
   There would be many studies of small amounts of Willow bark (Vitamin D2 instead of Vitamin D3)
   Then there would be a meta-analysis of aspirin and Willow Bark
   - That meta-analysis would conclude that aspirin and Willow bark do not work.

While about 200 RCTs will be published during 2014, I anticipate only adding 50 to the proofs table due to the reasons listed above
   Also, some trials will not get started due to lack of people willing to go for years with < 500 IU of vitamin D

See also VitaminDWiki: Random Controlled Trials with vitamin D intervention

More intervention trials for Vitamin D than for the TOTAL of Vitamins A + C + E + K combined

Vitamin D= 915, Others = 798 [ Vitamin A 188 + Vitamin C 269 + Vitamin E 236 + Vitamin K 105 ]   as of Sept 2012

See also VitaminDWiki


CLICK ON chart for more information and translation

See also the web

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