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8000 IU supplementation to people with various cancers – Nov 2010

Impact of oral vitamin D supplementation on serum 25-hydroxyvitamin D levels in oncology

Pankaj G Vashi email, Kristen Trukova email, Carolyn A Lammersfeld email, Donald P Braun email and Digant Gupta email
Nutrition Journal 2010, 9:60doi:10.1186/1475-2891-9-60, 23 November 2010

Background
Serum 25-hydroxyvitamin D [25(OH)D] is the major circulating form of vitamin D and a standard indicator of vitamin D status. Emerging evidence in the literature suggests a high prevalence of suboptimal vitamin D (as defined by serum 25(OH)D levels of <32 ng/ml) as well as an association between lower serum levels and higher mortality in cancer. We investigated the effect of oral vitamin D supplementation as a means for restoring suboptimal levels to optimal levels in cancer.

Methods
This is a retrospective observational study of 2198 cancer patients who had a baseline test prior to initiation of cancer therapy at our hospital to evaluate serum 25(OH)D levels between Jan 08 and Dec 09 as part of their initial nutritional evaluation. Patients with baseline levels of <= 32 ng/ml (n=1651) were considered to have suboptimal serum 25(OH)D levels and were supplemented with 8000 IU of Vitamin D3 (four 2000 IU D3 capsules) daily as part of their nutritional care plan. The patients were retested at their first follow-up visit. Of 1651 patients, 799 were available for follow up assessment. The mean serum 25(OH)D levels were compared in these 799 patients across the 2 time points (baseline and first follow-up) using paired sample t-test. We also investigated the factors associated with response to vitamin D supplementation.

Results
Of 2198 patients, 814 were males and 1384 females. 1051 were newly diagnosed and treated at our hospital while 1147 were diagnosed and treated elsewhere. The mean age at presentation was 55.4 years. The most common cancer types were breast (500, 22.7%), lung (328, 14.9%), pancreas (214, 9.7%), colorectal (204, 9.3%) and prostate (185, 8.4%). The mean time duration between baseline and first follow-up assessment was 14.7 weeks (median 10.9 weeks and range 4 weeks to 97.1 weeks). The mean serum 25(OH)D levels were 19.1 ng/ml (SD = 7.5) and 36.2 ng/ml (SD = 17.1) at baseline and first follow-up respectively; p <0.001. Patients with prostate and lung cancer had the highest percentage of responders (70% and 69.2% respectively) while those with colorectal and pancreas had the lowest (46.7% each). Similarly, patients with serum levels 20-32 ng/ml at baseline were most likely to attain levels >32 ng/ml compared to patients with baseline levels <20 ng/ml.

Conclusions
The response to supplementation from suboptimal to optimal levels was greatest in patients with prostate and lung cancer as well as those with baseline levels between 20-32 ng/ml. Characteristics of non-responders as well as those who take longer to respond to supplementation need to be further studied and defined. Additionally, the impact of improved serum 25(OH)D levels on patient survival and quality of life needs to be investigated.
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Giving 8000 IU to Cancer patients got about half back up to 32 ng/ml level in 8 weeks

The following table shows the detailed response vs cancer type.

A patient = responder if they got up to 32 ng/ml in 8 weeks

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As would be expected, many (65%) of those with <12 ng did not respond/replete to 32 ng/ml in the 8 weeks

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It is interesting to see the vitamin D levels before and after the 8 week supplementation vs cancer type

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It will be interesting in the future to see results of the next 8 weeks & 8,000 IU -as well as possible death rates of those who got the 8,000 IU vs standard death rates for those cancers

It seems clear, in hindsight, that they should have given more than 8,000 IU daily to those who were initially < 16 ng, or have started with a 50,000 or 100,000 IU repletion dose.

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See also at VitaminDWiki

Possible concern: Might get too much Chemotherapy if not adjust it down when increase vitamin D

See also at VitaminDWiki: BREAST CANCER

See also at VitaminDWiki: LUNG CANCER

See all files tagged with various kinds of cancer

Cancer - Bladder
Cancer – Breast
Cancer – Colon
Cancer – Melanoma
Cancer – Pancreatic
Cancer – Prostate
Cancer – General, others
Cancer - After

Following graph from the CDC August 2010
from PDF in File Gallery - More about vitamin D, also wiki

Imagine how many fewer cancers there could have been if the vitamin D levels were 50 ng instead of 20 ng

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Page last modified on 16 May, 2012


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List of attached files
ID Name desc uploaded Size Downloads Actions
306 gif Vitamin D levels vs cancer type - Nov 2010.gif 23 Nov., 2010 by admin 17.55 Kb 1524 View Download  
305 gif Response to 8000 IU vs initial blood level.gif 23 Nov., 2010 by admin 5.54 Kb 1453 View Download  
304 gif Response to 8000 IU vitamin D vs cancer - Nov 2010.gif 23 Nov., 2010 by admin 15.79 Kb 1456 View Download  
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