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Genes which regulate active vitamin D worsen with age – Oct 2016

Vitamin D, calcium homeostasis and aging.

Bone Res. 2016 Oct 18;4:16041. eCollection 2016.
Veldurthy V1, Wei R1, Oz L1, Dhawan P1, Jeon YH1, Christakos S1.
1Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers, The State University of New Jersey, New Jersey Medical School , Newark, NJ 07103, USA.

VitaminDWiki

Blood tests cannot detect changes in active vitamin D
Invisible Genes: Vitamin D Receptor, GC, CYP27B1, and CYP24A1

See also VitaminDWiki

Genetics category listing contains the following

331 articles in the Genetics category

see also

Vitamin D blood test misses a lot
in Visio for 2023

  • Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
  • Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
  • A Vitamin D test in cells rather than blood was feasible (2017 personal communication)
  •    Commercially available 2019
    • However, test results would vary in each tissue due to multiple genes
  • Good clues that Vitamin D is being restricted from getting to the cells
    1) A vitamin D-related health problem runs in the family
    2) Slightly increasing Vitamin D shows benefits (even if conventional Vitamin D test shows an increase)
    3) Vitamin D Receptor test (<$30) scores are difficult to understand in 2016
    • easier to understand the VDR 23andMe test results analyzed by FoundMyFitness in 2018

    4) Back Pain

Items in both categories Genetics and Seniors are listed here:

Vitamin D Receptor category has the following

510 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

See also: 47 studies in the Resveratrol category

It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
- - - - - - - -
The Vitamin D Receptor is associated with many health problems

Health problems include: Autoimmune (19 studies), Breast Cancer (22 studies), Colon Cancer (13 studies), Cardiovascular (23 studies), Cognition (16 studies), Diabetes (24 studies), Hypertension (9 studies), Infant (21 studies), Lupus (6 studies), Metabolic Syndrome (4 studies), Mortality (4 studies), Multiple Sclerosis (12 studies), Obesity (16 studies), Pregnancy (24 studies), Rheumatoid Arthritis (10 studies), TB (8 studies), VIRUS (36 studies),   Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation

55 health problems associated with poor VDR


A poor VDR is associated with the risk of 55 health problems  click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023  click here for details
Some health problem, such as Breast Cancer reduce the VDR

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR


How to increase VDR activation


Compensate for poor VDR by increasing one or more:

IncreasingIncreases
1) Vitamin D supplement  Sun
Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
etc
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D Receptor
13) Sulfroaphane and perhaps sulfurVitamin D Receptor
14)Butyrate especially gutVitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR
13 reasons why many seniors need more vitamin D (both dose and level) - July 2023 has the following

  1. Senior skin produces 4X less Vitamin D for the same sun intensity
  2. Seniors have fewer vitamin D receptor genes as they age
    Receptors are needed to get Vitamin D in blood actually into the cells
  3. Many other Vitamin D genes decrease with age
  4. Since many gene activations are not detected by a blood test,
    more Vitamin D is often needed, especially by seniors
  5. Seniors are indoors more than when they were younger
    not as agile, weaker muscles; frail, no longer enjoy hot temperatures
  6. Seniors wear more clothing outdoors than when younger
    Seniors also are told to fear skin cancer & wrinkles
  7. Seniors often take various drugs which end up reducing vitamin D
    Some reductions are not detected by a vitamin D test of the blood
    statins, chemotherapy, anti-depressants, blood pressure, beta-blockers, etc
  8. Seniors often have one or more diseases that consume vitamin D
    osteoporosis, diabetes, Multiple Sclerosis, Cancer, ...
  9. Seniors generally put on weight as they age - and a heavier body requires more vitamin D
  10. Seniors often (40%) have fatty livers – which do not process vitamin D as well
  11. Reduced stomach acid means less Magnesium is available to get vitamin D into the cells
  12. Vitamin D is not as bioavailable in senior intestines
  13. Seniors with poorly functioning kidneys do not process vitamin D as well
       Seniors category has 427 items

 Download the PDF from VitaminDWiki


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Osteoporosis is characterized by low bone mass and microarchitecture deterioration of bone tissue, leading to enhanced bone fragility and consequent increase in fracture risk. Evidence is accumulating for an important role of calcium deficiency as the process of aging is associated with disturbed calcium balance. Vitamin D is the principal factor that maintains calcium homeostasis. Increasing evidence indicates that the reason for disturbed calcium balance with age is inadequate vitamin D levels in the elderly. In this article, an overview of our current understanding of vitamin D, its metabolism, and mechanisms involved in vitamin D-mediated maintenance of calcium homeostasis is presented.
In addition, mechanisms involved in age-related dysregulation of 1,25(OH)2D3 action, recommended daily doses of vitamin D and calcium, and the use of vitamin D analogs for the treatment of osteoporosis (which remains controversial) are reviewed. Elucidation of the molecular pathways of vitamin D action and modifications that occur with aging will be an active area of future research that has the potential to reveal new therapeutic strategies to maintain calcium balance.

PMID: 27790378 DOI: 10.1038/boneres.2016.41

Clipped from PDF

  • “We and others have noted that renal CYP24A1, which limits the amount of 1,25 (OH)2D3 by accelerating the catabolism of 1,25(OH)2D3, increases with age.”
  • “In addition, with age there is a defect in 1 α hydroxylation.”
  • . . “there is also an age-related decrease in renal VDR and TRPV5 expression with age,” . .
  • “Some individuals, however, do not respond to vitamin D supplementation with an increase in 25(OH)D. The factors controlling this lack of response are unknown.”

Attached files

ID Name Comment Uploaded Size Downloads
7265 Aging VDR F2.jpg admin 30 Oct, 2016 18.32 Kb 765
7264 Vitamin D, calcium homeostasis and aging.pdf admin 30 Oct, 2016 283.72 Kb 973
7263 Aging VDR F1.jpg admin 30 Oct, 2016 17.07 Kb 789