Benefits of Vitamin D often limited by genes

Vitamin D (Cholecalciferol in blood, fat, breast milk)
Processing by Liver into 'Calcidiol is limited by
        CYP24A1 gene
Outside of the liver Calcidiol' production is limited by
       CYP2R1 gene
Measured Vit D = Calcidiol

It seems that ~30% of the people do not get full benefit from Vitamin D due to gene limitations
It seems that 20% of limitations due to genes are invisible to Vitamin D blood tests

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Genetics has the following charts
Vitamin D blood test misses a lot


Click on chart for details

See also VitaminDWiki

• Vitamin D Binding Protein category listing has 176 items along with related searches
• Genetics category listing has 332 items along with related searches
• Health problems that run in families are often associated with low vitamin D
• Genes make Multiple Sclerosis 2X more likely unless get more vitamin D - Aug 2015
• Pancreatic Cancer massively deregulates the local Vitamin D receptors and CPY24A1 – July 2014
• Gene differences can result in 14 ng difference in vitamin D levels– Feb 2014
• Common Vitamin D gene variants and resulting diseases – Jan 2013
• 2X higher risk of wheezing and asthma if modified receptor genes, even if vitamin D levels OK – Sept 2015
• Food allergy 12X more likely if low vitamin D and vitamin D binding gene problem – Aug 2015
• Hip Fracture 2.5 times more likely if poor Vitamin D Binding Protein gene - Aug 2015
• Crohn's disease associated with 7.6X deactivation of Vitamin D receptor – July 2015
• 2 Genes make AMD 6X more likely if low vitamin D - Aug 2015
• Alzheimer’s Disease is associated with genes which restrict vitamin D – Aug 2015

Vitamin D Receptor category has the following

512 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

See also: 47 studies in the Resveratrol category

It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
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The Vitamin D Receptor is associated with many health problems

Health problems include: Autoimmune (19 studies), Breast Cancer (22 studies), Colon Cancer (13 studies), Cardiovascular (23 studies), Cognition (16 studies), Diabetes (24 studies), Hypertension (9 studies), Infant (21 studies), Lupus (6 studies), Metabolic Syndrome (4 studies), Mortality (4 studies), Multiple Sclerosis (12 studies), Obesity (16 studies), Pregnancy (24 studies), Rheumatoid Arthritis (10 studies), TB (8 studies), VIRUS (36 studies),   Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation

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55 health problems associated with poor VDR

A poor VDR is associated with the risk of 55 health problems  click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023  click here for details
Some health problem, such as Breast Cancer reduce the VDR

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

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How to increase VDR activation

Compensate for poor VDR by increasing one or more:

Increasing	Increases
1) Vitamin D supplement  Sun Ultraviolet -B	Vitamin D in the blood and thus in the cells
2) Magnesium	Vitamin D in the blood  AND in the cells
3) Omega-3	Vitamin D in the cells
4) Resveratrol	Vitamin D Receptor
5) Intense exercise	Vitamin D Receptor
6) Get prescription for VDR activator    paricalcitol, maxacalcitol?	Vitamin D Receptor
7) Quercetin (flavonoid)	Vitamin D Receptor
8) Zinc is in the VDR	Vitamin D Receptor
9) Boron	Vitamin D Receptor ?, etc
10) Essential oils e.g. ginger, curcumin	Vitamin D Receptor
11) Progesterone	Vitamin D Receptor
12) Infrequent high concentration Vitamin D Increases the concentration gradient	Vitamin D Receptor
13) Sulfroaphane and perhaps sulfur	Vitamin D Receptor
14)Butyrate especially gut	Vitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR