Sublingual vitamin D


Sublingual supplements are a great boon for those who have problems taking even little capsules/pills

Many people have stated that sublinqual supplements get into the bloodstream faster - but we have been unable to confirm this so far

  • Note by VitaminDWiki Admin: My wife got took sublingual vitamin D and got allergy relief in <10 minutes, rather than the normal 6+ hours

Claim was made in a patent that there is less patient-to-patient variability to sublingual doses of the active form of vitamin D = CALCITRIOL


  • Sublingual Calcitriol might eliminate the variability of the stomach, gut, liver, and kidney
  • Sublingual vitamin D3 might eliminate the variability of the stomach and gut

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Vitamin D and the digestive system. - technical

Eur J Drug Metab Pharmacokinet. 2008 Apr-Jun;33(2):85-100.
Stumpf WE., University of North Carolina, Chapel Hill, NC, USA. stumpfwe at email.unc.edu

Target tissues of in vivo receptor binding and deposition of 1,25(OH)2 vitamin D3 and its oxygen analog OCT are reviewed in rats, mice, hamsters and zebra finch, identified with high-resolution microscopic autoradiography. Throughout the digestive system numerous sites with nuclear receptor binding of 3H-1,25(OH)2 vitamin D3 and 3H-OCT exist: in the oral region, epithelial cells of the oral cavity, tongue and gingiva, teeth odontoblast and ameloblast precursor pulp and stratum intermedium cells; in the parotid, submandibular and sublingual salivary glands, epithelial cells of striated ducts and granular convoluted tubules, intercalated ducts and acinar cells, as well as myoepithelial cells; in the stomach, neck mucous cells of gastric glands, endocrine cells of the antrum, and muscle cells of the pyloric sphincter; in the small and large intestine, absorptive and crypt epithelial cells; in the pancreas, predominantly islet B-cells. Perisinusoidal stellate (Ito) cells in the liver concentrate and retain variable amounts of radiolabeled compound in regions of their cytoplasm after administration of 3H-I,25(OH)2 vitamin D3 and 3H-25(OH) vitamin D3, probably sites of specific storage, similar to vitamin A. Submucosa in stomach and intestine also retain variable amounts of radiolabel, however unspecific with all compounds studied. In pilot studies with 3H-25(OH)2 vitamin D3 and 3H-24,25(OH)2 vitamin D3, no nuclear concentration was detectable. The reviewed data for vitamin D and its oxygen analogue OCT indicate genomic effects on multiple target tissues of the digestive system that involve cell proliferation and differentiation, endo- and exocrine secretion, digestion and absorption for maintaining optimal functions, with potentials for health prophylaxis and therapies. PMID: 18777944

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On the web

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Clipped from Natural Products Insider June 2010

While the authors use this B12 example to suggest there are no absorption advantages of one supplement delivery method vs. another,. . . .

As the authors noted, FDA has stated only products intended for ingestion can be legally marketed as dietary supplements in the United States. The agency has, in fact, written warning letters to companies, telling them: “Topical products and products intended to enter the body directly through the skin or mucosal tissues, such as transdermal or sublingual products, are not dietary supplements. For these products, both disease and structure/function claims may cause them to be new drugs.”

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Health Problems and D

  # of studies as of 7/21/14