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Statins and vitamin D

On the VitaminDWiki

Statins and Vitamin D in PubMed 159 items April 2014: examples follow:

  • Low plasma vitamin D levels and muscle-related adverse effects in statin users.Jan 2014 full free text
  • The association between drugs frequently used by the elderly and vitamin D blood levels: a review of observational and experimental studies.Feb 2014
  • Vitamin D3 effects on lipids differ in statin and non-statin-treated humans: superiority of free 25-OH D levels in detecting relationships Sept 2013
  • Effect of simvastatin/ezetimibe 10/10 mg versus simvastatin 40 mg on serum vitamin D levels. May 2013
  • Cardiovascular disease, statins and vitamin D. Feb 2012
  • Possible mechanisms of interaction between statins and vitamin D May 2012
  • Cholesterol levels, statins, vitamin D, and associated risk of pneumonia May 2012
  • Statins, vitamin D, and severe sepsis - Aug 2011
  • Vitamin D deficiency, myositis-myalgia, and reversible statin intolerance. - July 2011
  • Resolution of statin-induced myalgias by correcting vitamin D deficiency - May 2011
  • The relationship of vitamin D deficiency to statin myopathy - March 2011

Do statins increase the level of vitamin D in the blood in the short term?

Question: Is this a direct effect, or is it due to statins reducing cholesterol, which is needed to produce vitamin D from the skin, but cholesterol is not needed if the vitamin D is taken as a supplement

Some people appear to think that vitamin D could serve the same function as statins at much lower cost and much lower risk

Note: one statin is the top selling US prescription drug - with more sales than the next two top-selling drugs

Image

See also Web

See also Vitamin D Council April 2013 - behind a $5 paywall

  • Statins and heart health: Is vitamin D the missing link?
  • Did you know: Statins raise vitamin D levels
    . .market for statins nearly tripled when the National Cholesterol Education Program (NCEP) revised its guidelines to recommend statins as primary prevention.
    Lancet had an article about the recommendation: Are lipid-lowering guidelines evidence-based?” Lancet 369 (9557)
    8 of the 9 doctors on the NCEP panel were discovered to have been paid by statin manufacturers
    7 out of 8 studies later found that Statins raised levels of vitamin D

VitaminDWiki expects that Vitamin K2 could decrease the above side effects of statins


Rosuvastatin is a statin which increased vitamin D levels by 2.8X – Aug 2010

The JUPITER lipid lowering trial and vitamin D, Is there a connection?

William R Ware
Faculty of Science (Emeritus); University of Western Ontario; London, ON CA
Corresponding author. Correspondence to: William R. Ware; Email: warewr at rogers.com
Received May 6, 2010; Accepted August 3, 2010.
Dermatoendocrinol. 2010 Apr-Dec; 2(2): 50–54. doi: 10.4161/derm.2.2.13235

There is growing evidence that vitamin D deficiency significantly increases the risk of adverse cardiovascular events and that a vitamin D status representing sufficiency or optimum is protective. Unfortunately, in clinical trials that address interventions for reducing risk of adverse cardiovascular events, vitamin D status is not generally measured. Failure to do this has now assumed greater importance with the report of a study that found rosuvastatin at doses at the level used in a recent large randomized lipid lowering trial (JUPITER) had a large and significant impact on vitamin D levels as measured by the metabolite 25-hydroxyvitamin D. The statin alone appears to have increased this marker such that the participants on average went from deficient to sufficient in two months. The difference in cardiovascular risk between those deficient and sufficient in vitamin D in observational studies was similar to the risk reduction found in JUPITER.

Thus it appears that this pleiotropic effect of rosuvastatin may be responsible for part of its unusual effectiveness in reducing the risk of various cardiovascular endpoints found in JUPITER and calls into question the interpretation based only on LDL cholesterol and CRP changes. In addition, vitamin D status is a cardiovascular risk factor which up until now has not been considered in adjusting study results or in multivariate analysis, and even statistical analysis using only baseline values may be inadequate.

PMCID: PMC3081676


Text from the PDF

Rosuvastatin was given in doses of 10–20 mg/day and mean LDL levels decreased from 174 to 100 mg/dL.
At baseline the group had a mean level of 25(OH)D of 14 ng/mL which after 8 weeks of treatment increased to 36.3 ng/mL

PDF is attached at the bottom of this page


Benefits of Chocolate on the heart and all cause mortality (vs statins)

Green Med Info April 2012
Great many health benefits of chocolate documented -
Regarding just the heart: Chocolate appears to be better than statins.


Hypothesis of how statins can increase vitamin D blood levels, yet cause problems associated with vitamin D deficiency

Statins could decrease either the production or use of active vitamin D, that is, the form which is actually used in the body.
- suggested by Judy, Aug 2012


Simvastatin/Ezetimibe 10/10 mg increased Vitamin D levels 37%

Effect of Simvastatin/Ezetimibe 10/10 mg Versus Simvastatin 40 mg on Serum Vitamin D Levels.

J Cardiovasc Pharmacol Ther. 2013 Jan 2.
Liberopoulos EN, Makariou SE, Moutzouri E, Kostapanos MS, Challa A, Elisaf M.
Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece.

Backround:Low levels of 25-hydroxyvitamin D (25(OH)VitD) have been recognized as an emerging cardiovascular disease (CVD) risk factor. Statins are reported to increase 25(OH)VitD concentration. Animal studies suggest that ezetimibe is a moderate inhibitor of intestinal 25(OH)VitD absorption, but its effect in humans is unknown.Aim:To investigate whether combined treatment with simvastatin/ezetimibe 10/10 mg would increase 25(OH)VitD levels compared to simvastatin 40 mg monotherapy in patients with primary hypercholesterolemia.

METHODS:
In a Prospective Randomized Open-label Blinded End point study, 50 patients with primary hypercholesterolemia received either simvastatin/ezetimibe 10/10 mg (n = 25) or simvastatin 40 mg (n = 25) daily for 3 months. The primary end point was between-group difference in the change of serum 25(OH)VitD levels.

RESULTS:
Simvastatin/ezetimibe 10/10 mg was associated with a 36.7% increase in 25(OH)VitD serum levels (from 6.8 to 9.3 ng/mL, P = .000), while simvastatin 40 mg was associated with a 79.1% increase (from 6.7 to 12.0 ng/mL, P = .008). The increase in 25(OH)VitD levels in the simvastatin 40 mg group was significantly greater compared to that in the simvastatin/ezetimibe 10/10 mg group (P = .04). Both groups exhibited similar reductions in low-density lipoprotein cholesterol (LDL-C) levels.

CONCLUSION:
For similar LDL-C lowering simvastatin 40 mg is associated with greater increase in 25(OH)VitD compared to simvastatin/ezetimibe 10/10 mg.
Whether this difference is relevant in terms of CVD risk reduction is unknown.


A New Women’s Issue: Statins NYT May 2014

  • If you’re going to tell a healthy person to take a medicine every day for the rest of their life, you should have really good data that it’s going to make them better off,
  • statins didn’t prevent healthy women from having their first heart attacks and didn’t save lives.
  • Women who are healthy derive no benefit from statins, and even those women who have established heart disease derive only half the benefit men do.
  • The drugs have long been known to cause muscle pain in some people and, more rarely, liver and kidney damage, as well as cognitive side effects like memory loss and confusion
  • postmenopausal women who took part in the Women’s Health Initiative were much more likely to develop diabetes if they took statins, and diabetes itself increases the risk of heart disease considerably.

    Summary by VitaminDWiki: No proof that statins helps healthy women, but there is proof that statins harms them


Page last modified on 24 October, 2014


List of attached files
ID Name desc uploaded Size Downloads Actions
1172 pdf Jupiter PMC3081676.pdf PDF 25 Mar., 2012 by admin 261.78 Kb 598 View Download  
152 gif List of best selling drugs wikipedia - 2006.gif best selling drugs 18 Aug., 2010 by admin 21.88 Kb 6427 View Download  
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Health Problems and D

  # of studies as of 9/30/14