Sclerodoma and vitamin D deficiency


Epidemiology (which includes many of the hints that it can be prevented with vitamin D)

This disease is found among all races worldwide, but women are four times more likely to develop scleroderma than men. In the United States, approximately one person in 1,000 is affected. Children rarely suffer the systemic type, but localized scleroderma is common. Most adults are diagnosed after their 30th birthday and before age 50. The disease has high rates among the native American Choctaw tribe and African-American females.[7]

From Sclerodoma Organization

The cause of scleroderma is largely unknown.

Advanced Glycation Endproducts
—B Cells and T Cells
Cluster Studies (Main Page)
—Cluster in South Boston
Dendritic Cells
Drugs and Medications
Environmental (Main Page)
—Artificial Joints & Breast Implants
—Drugs and Medications
—Mercury (Dental Amalgam)
—Silica Exposure
—Vinyl Chloride
Fetal Cells
Gluten Sensitivity
Hormones and Chromosomes
Molecular Defect
Natural Killer Cells
Oxidative Stress, Lipid Peroxidation
Platelet Aggregation
Serum TIMP-2
Tissue Kallikrein
Vitamin D Deficiency at http://sclero.org/medical/causes/vitamin-d-deficiency/a-to-z.html


Vitamin D's major biological function is to maintain normal blood levels of calcium and phosphorus. Recent studies have demonstrated that individuals with low blood levels of vitamin D are at a higher risk of developing autoimmune diseases.
Dietary Supplement Fact Sheet: Vitamin D. Information about the popular supplement from Office of Dietary Supplements. National Institutes of Health. (Also see: Supplements)
Study: Exercise, tea and vitamin D to ward off dementia. Improved living and diet habits — including lots of physical activity, regular tea-drinking and sufficient vitamin D levels — could reduce the risk of brain decline, according to three studies. USA Today. July 11, 2010 (Also see: Foods and Health)
What lies behind the vitamin D revolution? We now recognize that vitamin D transcends the definition of a mere vitamin: It is actually a prohormone, and vitamin D receptors are expressed by cells in most organs, including the brain, heart, skin, gonads, prostate gland, and mammary glands. Ronald L. Hoffman, MD. Cortlandt Form. 03/08/10.
The ABCs of Ds. If you live in the Great White North, is virtually impossible to generate through your skin as of mid-October. Since it's really tough to get much from your diet (oily fish, or supplemented in milk, yogurt and margarine), that means now's the time to crack open the pill bottles. Jennifer Sygo. National Post. Canada.com. October 2009.
How much vitamin D should someone over 55 take? Vitamin D is essential for promoting calcium absorption in the gut, build and preserve bone, helps prevent osteoporosis and helps decrease fracture risk. In addition, vitamin D may help in the prevention or treatment of type 1 diabetes, some cancers, and autoimmune diseases. Dr. Melina Jampolis. CNMHealth.com. 03/20/09.

Autoimmune Diseases and Vitamin D

Insights into endocrine-immunological disturbances in autoimmunity and their impact on treatment. The vitamin D endocrine system is regarded as a potential immunosuppressive factor. Consequently, estrogens (especially in patients affected by B cell-driven immunity) and melatonin should be avoided and glucocorticoids (as replacement therapy) and vitamin D are allowed in treatment of autoimmunity. M. Cutolo. Arthritis Research & Therapy. April 6 2009. (Also see: Hormones)
Vitamin D or hormone D deficiency in autoimmune rheumatic diseases, including undifferentiated connective tissue disease (UCTD). Epidemiological evidence indicates a significant association between vitamin D deficiency and an increased incidence of autoimmune diseases. Patients with undifferentiated connective tissue disease also show vitamin D deficiency and, interestingly, patients who progress into CTDs had the lower vitamin D levels than those who remained in UCTD stage. M. Cutolo. Arthritis Research & Therapy. Dec 2 2008. (Also see: UCTD)
Vitamin D deficiency in Undifferentiated Connective Tissue Disease (UCTD). Our results suggest that vitamin D deficiency in UCTD patients may play a role in the subsequent progress into well-defined CTDs. E. Zold. Arthritis Research & Therapy. October 18, 2008. (Also see: UCTD)
Review: Vitamin D, immunity and lupus. Patients with autoimmune diseases such as multiple sclerosis, rheumatoid arthritis and systemic lupus erythematosus show low 25-OH vitamin D serum levels. (Sage Journals) Lupus, Vol. 17, No. 1, 6-10 (2008). (Also see: Autoimmunity)

Deficiencies of Vitamin D

Vitamin D Deficiency in a Cohort of Patients with Systemic Scleroderma (SSc) from the South of Spain. Vitamin D deficiency in SSc seems to be high in different European populations, but studies with a greater number of patients are required to identify the exact role of vitamin D deficiency not only in development of osteopenia, but also in different manifestations of the disease, including systolic pulmonary artery pressure (sPAP), disease activity, and presence of lung fibrosis. Raquel Rios Fernandez, MD. The Journal of Rheumatology June 1, 2010 vol. 37 no. 6 1355.
Low bone mass in juvenile onset sclerosis systemic (JoSSc): the possible role for 25-hydroxyvitamin D (250HD) insufficiency. We have identified a remarkable high prevalence of 25OHD insufficiency in JoSSc. Its correlation with hip bone mineral apparent density (BMAD) suggests a causal effect and reinforces the need to incorporate this hormone evaluation in this disease management. Samuel Katsuyuki Shinjo (SpringerLink) Rheumatology International 25 March 2010. (Also see: Juvenile Scleroderma)
Measurement uncertainty of 25-OH vitamin D determination with different commercially available kits: impact on the clinical cut offs. Results show that, whatever the assay, the “true” 25(OH)D of a patient will be >80 nmol/L if its measured concentration is >100 nmol/L. In other words, if a physician considers that a normal Vitamin D status is defined by a 25(OH)D level ?80 nmol/L, he should ensure that the patients present a 25(OH)D ?100 nmol/L. E. Cavalier Osteoporosis International. September 15, 2009.
Vitamin D Deficiency and Insufficiency in 2 Independent Cohorts of Patients with Systemic Sclerosis. Vitamin D deficiency was very common in the 2 SSc populations, independent of geographic origin and vitamin D supplementation. This suggests that common vitamin D supplementation does not correct the deficiency in SSc patients, and that a higher dose is probably needed, especially in those with high inflammatory activity or severe disease. Alessandra Vacca J Rheumatol vol. 36 no. 9 1924-1929. September 2009.
Chronic pain linked to low vitamin D. The study also found the patients with the lower levels of vitamin D self-reported worse physical functioning and worse overall health perception. UPI.com. 03/23/09. (Also see: Pain)
Vitamin D, Parathyroid Hormone, and Acroosteolysis in Systemic Sclerosis. Low levels of vitamin D may reflect silent malabsorption and might be a risk factor for secondary hyperparathyroidism and bone resorption. Y. Braun-Moscovici. J Rheumatol. Oct 1 2008. (Also see: Calcinosis, Acroosteolysis, and Bone Resorption)

Sunshine and Scleroderma

Safe Sun Protection. For people with specific autoimmune disorders, protection from the sun should be a serious perennial consideration.
Conditions such as Lupus, dermatomyositis, scleroderma and vitaligo are autoimmune diseases that are sun-sensitive. Mary Jo DiLonardo. Arthritis Today. July 2009.
Do You Have an Autoimmune Disease? Why You Should Beware of the Sun. The sun’s effects may reach through skin and ‘punish’ the immune system. People with scleroderma, too, can be affected by sun exposure, says Frederick Wigley, MD, director of the Johns Hopkins Scleroderma Center in Baltimore. While they don’t have the same blistering or flares associated with lupus, the sun can cause further damage to skin already hardened and damaged by the disease. Also, some people with scleroderma have hyperpigmentation of the skin that is made worse by sun exposure. Arthritis Today, July-August 2005.

Sunshine and Vitamin D

Sunshine could be key to getting enough Vitamin D. Vitamin D deficiency is a common complaint in prenatal diets, but simply getting a bit more sunshine during pregnancy could hold the key to boosting productions of it. Pregnant mothers are particularly liable to develop vitamin D deficiency, and so they are at increased risk of developing autoimmune diseases. Bounty News. 03/08/07. (Also see: Pregnancy and Scleroderma)
D-Hormone and the Immune System. D-hormone [1,25(OH)2 D3] is an important immune system regulator that has been shown to inhibit development of autoimmune diseases including experimental inflammatory bowel disease (IBD), rheumatoid arthritis (RA), multiple sclerosis (MS), and type 1 diabetes. J Rheumatol 2005 September;32 Suppl 76:11-20.
Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Sensible sun exposure (usually 5-10 min of exposure of the arms and legs or the hands, arms, and face, 2 or 3 times per week) and increased dietary and supplemental vitamin D intakes are reasonable approaches to guarantee vitamin D sufficiency. PubMed. Am J Clin Nutr. 2004 Dec;80(6):1678S-88S.

Supplementation of Vitamin D

Before taking supplements of any kind, consult with your physicians.
Time to start the Vitamin D supplements again. Research continues to strengthen the theory that this vitamin has been significantly underestimated over the years. Studies have consistently linked low levels of Vitamin D with breast, prostate, and colon cancer, heart disease, diabetes and numerous other autoimmune disorders. As physicians make Vitamin D level testing part of their routine testing, some are finding that almost 60% of their patients are low. The Daily Gleaner. 09/27/08.
Why Should Rheumatologists Consider Vitamin D Supplementation for their Patients? Given the low cost of vitamin D, its excellent tolerability, combined musculoskeletal- and suggested antiinflammatory/ cardio-vascular benefits, vitamin D supplementation holds a significant public health potential. IngentaConnect. Current Rheumatology Reviews, Vol 3, No 2, May 2007, pp. 129-134(6). (Also see: Rheumatoid Arthritis)

See also VitaminDWiki

See also PubMed

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