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Migraine and Vitamin D

Dr. Gominak in Texas has some interesting ideas about Migraine, Sleep and Vitamin D

see new publication by Dr. Gominak Nov 2011 Poor sleep and lack of vitamin D - Nov 2011

CLICK HERE for her web page on Migraine and Vitamin D

Notes from PDF CLICK HERE for PDF

  • Migraine pain transmitters are mutant genes which turn on the pain receptors evolved to be activated only with concussions.
  • If you do not have a migraine gene a sleep disorder will not cause headache pain.
  • "Most patients with daily headache have a primary sleep disorder, either sleep apnea, restless leg syndrome or periodic limb movements of sleep.” Page 35
  • 'Most of these patients have vitamin D deficiency with or without accompanying B12 deficiency

Measure D 25OH, B12, iron and replace all that are low (page 35)

  • Vitamin D 70- -85 nanograms/ ml.
  • B12 > 500/ml.“

Any migraine theory has to explain (page 37)

  • Why do migraines start at puberty?
  • Why do they start in boys and girls around the same age but get much better in boys?
  • Why are they worse around the menses?
  • Why are they much worse perimenopausally?
  • Why do they go away after menopause?

See also in VitaminDWiki

Note: Magnesium is more than a cofactor for vitamin D

See also web

  • FDA approved TMS device for headache - Dec 2013
    Based on a single RCT and diary entries of 100 people
    Side effects from the device were rare, the FDA said, but included "single reports of sinusitis, aphasia (inability to speak or understand language) and vertigo."
    Rare? with only 100 people, Minor?

Wonder how many of the following RCT would get FDA approval if significant effort was applied?

68 health problems prevented or treated

Health Problem
Treat
Prevent
Reduction by Vit D
   click for details
RCT = Random Controlled Trial
   * = link to additional RCT
CT = Clinical Trial
HypertensionT 149 to 142 mm Hg RCT*  *, 2400 IU.  100,000 IU*
Cardiovascular after attack T 32 % fewer deaths CT 1000 IU
Diabetes Type 1 P 85 % 12000 kids, 2000 IU
Diabetes Type 2T 62 % RCT* *, CRP reduction, 4000 IU
Back Pain T 95 % 5000/10000 IU
Influenza P 90 % RCT *, 2000 IU
Falls P 19 %RCT, 1000 IU
Hip Fractures P 30 % RCT * 800 IU
Rickets P 98 % Turkey, 400 IU
Raynaud's Syndrome T 40 % RCT, visual scale, 20000 IU Avg
Menstrual pain P 76 % RCT, 7000 IU Avg, PMS reduced by half
Pregnancy risks P 50 % RCT, 4000 IU
C-section, unplanned P 50 % RCT, 4000 IU, small study
Low birth weight P 60 % RCT * 1000 IU of D2
TBP 60 % RCT, 800 IU
Breast Cancer P 60 % RCT, 1100 IU (2007)
Rheumatoid Arthritis pain T 40 % RCT, 500 IU, added to prescription
Cystic Fibrosis T 75 % RCT, pilot 4X fewer deaths 250,000 IU
Chronic Kidney T 90 to 70 PTH RCT, 3500 IU,
Respiratory Tract Infection P 63 % RCT, 4000 IU 1 year 2nd RCT: 2000/800 IU
3rd RCT 20,000 IU weekly
Lupus T zero flares Loading then 100,000 IU monthly, RCT too
Sickle Cell T Less pain RCT, up to 100,000 IU/week
Leg ulcer healing T 4X faster RCT, 50,0000 IU/week, small study
Traumatic Brain Injury T 2X RCT, 20,0000 IU/day with progesterone
Parkinson's DiseaseT StabilizedRCT, 1200 IU/day
Multiple SclerosisP 68%RCT, 7100 IU prevent pre-MS ==> MS
Congestive Heart Failure T 90 % RCT, 1000 IU infants (also: Adults, not RCT)
Middle Ear Infection P 30 % RCT, 1000 IU infants
GingivitisT 88 %RCT, 2000 IU
Muscle in seniors T 17 % more muscle RCT, 4000 IU
Antibiotic use when >70y T 47 % RCT, 60,000 IU monthly
Infants tallerBenefit1 cm tall RCT, 50,000 IU weekly, 8 weeks
Gestational Diabetes T Treated RCT, 2 doses of 50,000 IU
After Heart Attack T +6% ejection fraction RCT, 800,000 IU one time
Prostate Cancer T Fewer +cores RCT, 4000 IU (2012)
Asthma T Reduced symptoms RCT, 60K IU/month;   RCT 50K IU/week
Meta-analysis of Asthma intervention
Depression T Reduced RCT, 300,000 IU injection RCT helped Prozac
Low vitamin D while breastfed P All infants > 20 mg RCT, 5,000 IU
Fibromyalgia T Reduced RCT, 30-48 ng   RCT 50K IU/week
Hives, Chronic T Reduced 40% RCT, 4000 IU added
CholesterolT Reduced 4 mg RCT, 400 IU + Ca
Weight Loss T lost 5 more lbs RCT, 2000 IU +diet +exercise
Multiple Sclerosis T 95% were CURED 20,000 to 140,000 IU/day
Gestational DiabetesP 40% RCT * , 5,000 IU
Chronic Obstructive
Pulmonary Disease
T 17X improvement CT, 50,000 IU weekly
RCT 100,000 IU monthly
Asthma T 1/2 Asthma attacks RCT >42 mg of vitamin D
Quality of Life (QoL) T Nursing Home QoL CT, 4,000 IU in daily bread
Death of Critically Ill Patients T 20% increase in survivability RCT 540 K IU loading than 90K monthly
Restless Leg Syndrome T Score 26 ==> 10 CT, Vitamin D dose size not state in abstract
Hepatitis-C T Enhanced conventional drugs RCT 2.000 IU
Chron's disease? T improved when > 30 ngRCT 2,000 IU
Pre-term birth P 2.5X decrease, also:
fewer c-section & better Apgar
RCT 2,000 IU India
Lupus T Pain reduced RCT 4,000 IU
Cluster headaches T CH eliminated in 60% 10,000 IU, Mg, Omega-3, etc
Autism T 80% improved CT 300 IU/kg/day for 3 months
PreDiabetes T ~20% reduced RCT 60,000 IU/month
Weight loss:
Overweight and Obese
T 12 lbs in 6 months RCT 100,000 IU/month
Sarcopenia = muscle loss T 27% increase RCT 1,000 IU
Growing Pains T 60% decrease ~100,000 IU/month -NOT RCT, given to all
2nd study, similar results
Osteoarthritis pain T 60% decrease 50,000 IU/weekly - NOT RCT, given to all
Amyotrophic Lateral Sclerosis T helped 2,000 IU - NOT RCT, given to all
Vertigo T 3X reduction if raised > 10ng 600,000 IU load, then maint. - NOT RCT, given to all
Warts T 80% eliminated injection NOT RCT, given to all
Metabolic Syndrome P reduced 44% when VitD
increased by 30 ng
NOT RCT -given to all
Hay fever P 1,000 IU for 30 days RCT
Preeclampsia P 50,000 IU every 2 weeksRCT
Blood cell cancer T Multiple MyelomaNOT RCT -given to all
Irritable Bowel Syndrome? T 3,000 IU sprayRCT


You can click underlined items to get details    Short url for this table =    is.gd/proofvitd
Note: virtually all of the above RCT proofs have a larger benefit that that shown for the TMS device
AND have far fewer side effects



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