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Diseases which are related due to vitamin D deficiency

Many studies have discovered associations between diseases
but typically they have not noticed the likely vitamin D connections

Hypothesis: Having one vitamin D disease increases the probability of another,
especially if disease reduces vitamin D

see wikipage: http://www.vitamindwiki.com/tiki-index.php?page_id=1817
Diseases listed in graph:
Prostate cancer, Breast cancer, Bladder cancer, Skin Cancer, Osteoporosis, Rickets, MS, Falls/fractures Diabetes, Influenza, Kidney, Depression, Chronic fatigue, Birth problems, SAD, Pancreas, Overweight, Heart disease, Lupus, Chronic Pain, ALS, TB, IBD, COPD, Colds, Cognitive Decline, Psorasis, Bone density/fractures

Update: Strong association to other vitamin D deficiency diseases - 12 years in UK July 2013

Addison's disease, ankylosing spondylitis, autoimmune hemolytic anemia, chronic active hepatitis, celiac disease,
Crohn's disease, diabetes mellitus, pemphigoid, pernicious anemia, primary biliary cirrhosis, rheumatoid arthritis,
Sjogren's syndrome, systemic lupus erythematosus, thyrotoxicosis, and significantly reduced risks for asthma and myxoedema.

Some of the associations seen so far

Comorbidity = associated disease: examples

Predicted possible associations (not yet reported)

The mechanisms to lower the vitamin D level in the blood include:

  • Reduce vitamin D intake
    From the sun - too sick/frail/obese to get out in the sun, fear additional skin cancer
    From the gut - colon surgery, bariatric surgery, IBD, Celiac Disease, Crohn's
  • Consume vitamin D
    • Short term - pregnancy, surgery, trauma
    • Obesity - stores vitamin D in the fat, leaving less in the blood
    • Smoking (not really a disease)
    • Diseases - MS, Diabetes, HIV (also restricts conversion by Kidney damage)
    • Some statins (not all)
  • Conflict with vitamin D
  • Reduce the conversion of vitamin D into the active form used in the blood
  • Reduce the storage of vitamin D in the body

Most of these problems can be reduced by getting more vitamin D

The more the better - up to a limit

Some of the vitamin D deficiencies are short term

  • Pregnancy (especially low vitamin D if have twins or if closely spaced pregnancies)
  • Surgery or trauma
  • Season - typically winter, but also extremely hot summers - if people can avoid intense heat with air conditioners


Image

CLICK ON chart for more information

Titles of Letters to editor and articles in VitaminDWiki by Dr. WB Grant which appear to relate to this theory

  • Statins, vitamin D, and neuropathic pain - July 2011
  • Vitamin D might reduce some vascular risk factors and, consequently, risk of dementia Jan 2011
  • Pregnant women are at increased risk for severe A influenza because they have low serum 25-hydroxyvitamin D levels - Sept 2010
  • Low vitamin D may explain the link between preeclampsia and cardiovascular disease - March 2010
  • Cause of death in older men after the diagnosis of prostate cancer - Sept 2009
  • High vitamin D and calcium requirements during pregnancy and tooth loss - Nov 2008 full text online
  • Vitamin D, periodontal disease, tooth loss, and cancer risk - July 2008

See also VitaminDWiki

25 X more likely to have senior moment
23 X more likely to have vertigo
19 X more likely to get dementia
17 X more likely to have muscle inflammation
14 X more likely to die after first cardiovascular event
12 X more likely to die from elderly pneumonia
11 X more likely to be allergic to peanuts
10 X more reactions to flu vaccine
7 X more likely to have low birth weight infant
7 X more likely to have leg pain
7 X increased chance of death if coronary artery disease
8 X more likely to get lupus
6 X more likely to get hip fracture after stroke
6 X more likely to die after coronary bypass
6 X more likely to have allergic rhinitis
6 X more likely to get diabetes if abdominal obese
6 X more likelihood of cancer in children
5.8 X more likely to have coronary artery disease
5.8 X more likely to get ovarian cancer if have a specific gene
5.5 X more likely to have low bone mineral density
5 X more likely to have facial skin aging
5 X more likely to get urinary tract infection
5 X more likely to get restless leg syndrome
5 X more likely to get vaginosis during pregnancy
4.7 X more likely to get a common superbug
4.7 X more likely to need feeding help in nursing home
4 X more likely to have preeclampsia during pregnancy
4 X more likely to have C-section
4 X more likely to have psychiatric disorders as a teen
4 X more likely to have childhood asthma
4 X more likely to have metabolic syndrome
3.9X more likely to get non-TB lung disease
3.7 X more likely to be frail when elderly
3.5 X more likely to get type 1 diabetes
3.5 X more likely for black children to get forearm fractures
3.5 X more likely to have psychosis if dark skinned
3.3 X more likely to have full-on multiple sclerosis
3 X more likely to get triple negative breast cancer
3 X more likely to have advanced-stage cancer
3 X more colds when overweight
3 X more likely to die after being in ICU for 2 days
Note: These are typically the ratios between groups having > 30 ng/ml and those having < 10 ng/ml

Short url = http://is.gd/deficiencydiseases



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Health Problems and D

  # of studies as of 12/20/14