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Cancer deaths of senior women 60 percent more likely if low Vitamin D – March 2015

Vitamin D and cancer mortality in elderly women

Germaine Wong 123 germaine.wong at health.nsw.gov.au, Wai Hon Lim 45, Joshua Lewis 46, Jonathan C Craig 12, Robin Turner 2, Kathy Zhu 46, Ee Mun Lim 7 and Richard Prince 46
BMC Cancer 2015, 15:106 doi:10.1186/s12885-015-1112-5, Published: 8 March 2015

Background There is increasing evidence that vitamin D deficiency is a risk factor for cancer, however it remains uncertain whether vitamin D deficiency also predisposes to death from cancer. The aim of the study was to determine the association between serum 25-hydroxy-vitamin D (25 (OH) D) concentrations and cancer-specific mortality in a community-based cohort of older post-menopausal women.

Methods Cox proportional regression analyses were conducted to examine the association between serum 25 (OH) D concentrations and the risk of overall and site-specific cancer mortality in a cohort of elderly women.

Results Over a median follow-up time of 10 years, a total of 84 cancer deaths were observed. Women with lower serum 25 (OH) D concentrations were at an increased risk of cancer death, but not for incident cancer.

The excess risk for cancer death was observed with serum 25 (OH) D concentration less than 64 nmol/L (the median value) [adjusted HR: 1.61 (95% CI: 1.02 - 2.54, p = 0.04].

For every 30 nmol/L reduction in serum 25 (OH) D concentrations, there was a 30% increase in the overall risk of cancer death [adjusted HR: 1.33; 95% CI: 1.03 – 1.72, p = 0.02].

The excess risk appeared to be site-specific and greatest in those with haematological cancers [adjusted HR: 2.13: 95% CI: 1.0 – 4.55, p = 0.05].

Conclusions In elderly women, lower serum 25 (OH) D concentrations appear to be an independent risk factor for cancer-specific mortality, but not a risk factor for the development of cancer.
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List of attached files
ID Name desc uploaded Size Downloads Actions
5147 jpg Risk vs types of cancer.jpg 08 Mar., 2015 by admin 31.68 Kb 307 View Download  
5146 jpg Cancer Mortality.jpg 08 Mar., 2015 by admin 18.63 Kb 289 View Download  
5145 jpg Mortality 26 ng.jpg 08 Mar., 2015 by admin 31.96 Kb 311 View Download  
5144 pdf Vitamin D and cancer mortality in elderlywomen.pdf PDF 2015 08 Mar., 2015 by admin 1.20 Mb 298 View Download  
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